======= BRAF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRAF
  * **<color #00a2e8>Official Name</color>**: B-Raf proto-oncogene, serine/threonine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=673|673]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15056|P15056]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRAF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRAF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164757|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 1|
|Pkinase Tyr|
|RBD|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trehalose metabolism in response to stress|
|trehalose metabolic process|
|disaccharide metabolic process|
|small GTPase binding|
|positive regulation of glucose transmembrane transport|
|oligosaccharide metabolic process|
|regulation of glucose transmembrane transport|
|cellular response to calcium ion|
|positive regulation of peptidyl-serine phosphorylation|
|regulation of peptidyl-serine phosphorylation|
|response to calcium ion|
|cellular carbohydrate metabolic process|
|cellular response to metal ion|
|positive regulation of transmembrane transport|
|positive regulation of ERK1 and ERK2 cascade|
|cellular response to inorganic substance|
|protein kinase activity|
|establishment of protein localization to membrane|
|regulation of ERK1 and ERK2 cascade|
|protein serine/threonine kinase activity|
|response to metal ion|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|carbohydrate metabolic process|
|protein localization to membrane|
|response to inorganic substance|
|positive regulation of MAPK cascade|
|regulation of transmembrane transport|
|intracellular membrane-bounded organelle|
|calcium ion binding|
|regulation of MAPK cascade|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|animal organ morphogenesis|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|identical protein binding|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|phosphorylation|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nras|NRAS]]|0.509|
|[[:human genes:p:prkce|PRKCE]]|0.486|
|[[:human genes:r:raf1|RAF1]]|0.434|
|[[:human genes:s:shoc2|SHOC2]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4083
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRAF Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>