======= BRK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRK1
  * **<color #00a2e8>Official Name</color>**: BRICK1 subunit of SCAR/WAVE actin nucleating complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55845|55845]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUW1|Q8WUW1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611183|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q91VR8, ECO:0000269|PubMed:18560548}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Arp2/3 complex-mediated actin nucleation|
|SCAR complex|
|positive regulation of actin nucleation|
|regulation of Arp2/3 complex-mediated actin nucleation|
|positive regulation of lamellipodium assembly|
|Rac protein signal transduction|
|regulation of actin nucleation|
|positive regulation of lamellipodium organization|
|regulation of lamellipodium assembly|
|protein homotrimerization|
|regulation of lamellipodium organization|
|Rac GTPase binding|
|protein trimerization|
|vascular endothelial growth factor receptor signaling pathway|
|positive regulation of actin filament polymerization|
|positive regulation of plasma membrane bounded cell projection assembly|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|actin filament organization|
|Fc receptor signaling pathway|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|protein-containing complex binding|
|small GTPase mediated signal transduction|
|phagocytosis|
|protein homooligomerization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|regulation of cellular component size|
|in utero embryonic development|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|immune response-activating signal transduction|
|actin filament-based process|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|embryo development|
|identical protein binding|
|cell motility|
|localization of cell|
|immune effector process|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|regulation of immune system process|
|intracellular signal transduction|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.88|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.85|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.86|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17864
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRK1 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>