======= BRPF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRPF1
  * **<color #00a2e8>Official Name</color>**: bromodomain and PHD finger containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7862|7862]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55201|P55201]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRPF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRPF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653, PubMed:27939640). Preferentially mediates histone H3-K23 acetylation (PubMed:27939640). Positively regulates the transcription of RUNX1 and RUNX2 (PubMed:18794358). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:27939640}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHD|
|PWWP|
|Bromodomain|
|EPL1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-K23 acetylation|
|histone acetyltransferase activity (H3-K23 specific)|
|MOZ/MORF histone acetyltransferase complex|
|histone H3 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|regulation of signal transduction by p53 class mediator|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.2|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.13|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.11|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.01|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.96|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.87|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.84|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.83|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.77|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.7|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.7|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.74|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.89|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.91|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.13|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.17|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.42|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.69|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.66|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:znf592|ZNF592]]|0.574|
|[[:human genes:i:id3|ID3]]|0.557|
|[[:human genes:m:med13l|MED13L]]|0.55|
|[[:human genes:n:nsd1|NSD1]]|0.548|
|[[:human genes:m:mllt1|MLLT1]]|0.528|
|[[:human genes:t:trim28|TRIM28]]|0.519|
|[[:human genes:t:taf5l|TAF5L]]|0.515|
|[[:human genes:c:ccdc101|CCDC101]]|0.495|
|[[:human genes:k:kat6a|KAT6A]]|0.492|
|[[:human genes:m:med23|MED23]]|0.491|
|[[:human genes:w:wdr24|WDR24]]|0.491|
|[[:human genes:t:taf6l|TAF6L]]|0.48|
|[[:human genes:t:tada1|TADA1]]|0.475|
|[[:human genes:m:med13|MED13]]|0.475|
|[[:human genes:s:ssbp2|SSBP2]]|0.475|
|[[:human genes:t:tada3|TADA3]]|0.473|
|[[:human genes:k:kat2a|KAT2A]]|0.462|
|[[:human genes:s:supt7l|SUPT7L]]|0.461|
|[[:human genes:z:zmiz1|ZMIZ1]]|0.46|
|[[:human genes:s:setdb1|SETDB1]]|0.458|
|[[:human genes:z:zmynd8|ZMYND8]]|0.452|
|[[:human genes:t:tle4|TLE4]]|0.451|
|[[:human genes:b:bap1|BAP1]]|0.45|
|[[:human genes:m:meaf6|MEAF6]]|0.449|
|[[:human genes:t:tada2b|TADA2B]]|0.448|
|[[:human genes:c:celf1|CELF1]]|0.448|
|[[:human genes:d:dohh|DOHH]]|0.445|
|[[:human genes:l:ldb1|LDB1]]|0.442|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.439|
|[[:human genes:i:ing5|ING5]]|0.434|
|[[:human genes:v:vcpip1|VCPIP1]]|0.433|
|[[:human genes:d:dcaf7|DCAF7]]|0.433|
|[[:human genes:e:erg|ERG]]|0.432|
|[[:human genes:s:scaf8|SCAF8]]|0.431|
|[[:human genes:m:mtor|MTOR]]|0.43|
|[[:human genes:r:rptor|RPTOR]]|0.426|
|[[:human genes:u:usp22|USP22]]|0.425|
|[[:human genes:h:hhex|HHEX]]|0.424|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.423|
|[[:human genes:a:atf7ip|ATF7IP]]|0.421|
|[[:human genes:a:ahcyl1|AHCYL1]]|0.418|
|[[:human genes:r:runx1|RUNX1]]|0.416|
|[[:human genes:s:spag7|SPAG7]]|0.416|
|[[:human genes:m:maml1|MAML1]]|0.416|
|[[:human genes:b:bptf|BPTF]]|0.413|
|[[:human genes:p:papola|PAPOLA]]|0.412|
|[[:human genes:o:otud5|OTUD5]]|0.411|
|[[:human genes:m:mef2c|MEF2C]]|0.409|
|[[:human genes:f:fli1|FLI1]]|0.408|
|[[:human genes:m:med10|MED10]]|0.406|
|[[:human genes:a:azin1|AZIN1]]|0.405|
|[[:human genes:u:ube2l3|UBE2L3]]|0.404|
|[[:human genes:d:ddx5|DDX5]]|0.401|
|[[:human genes:u:ube2g1|UBE2G1]]|0.401|
|[[:human genes:z:znf608|ZNF608]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1044
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRPF1 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>