======= BSG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BSG
  * **<color #00a2e8>Official Name</color>**: basigin (Ok blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=682|682]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35613|P35613]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BSG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BSG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].  Sequence Note: This RefSeq record represents the BSG*001.1.1 allele. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. {ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:28666119}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to mercury ion|
|dendrite self-avoidance|
|acrosomal membrane|
|cell-cell adhesion mediator activity|
|mannose binding|
|decidualization|
|maternal placenta development|
|embryo implantation|
|neuron recognition|
|maternal process involved in female pregnancy|
|extracellular matrix disassembly|
|pyruvate metabolic process|
|odontogenesis of dentin-containing tooth|
|response to cAMP|
|sarcolemma|
|melanosome|
|odontogenesis|
|response to organophosphorus|
|placenta development|
|response to purine-containing compound|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|female pregnancy|
|protein localization to plasma membrane|
|multi-multicellular organism process|
|membrane raft|
|protein localization to cell periphery|
|cell recognition|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|axon guidance|
|neuron projection guidance|
|axon|
|cadherin binding|
|extracellular matrix organization|
|response to metal ion|
|axonogenesis|
|leukocyte migration|
|extracellular structure organization|
|response to peptide hormone|
|cellular component disassembly|
|axon development|
|focal adhesion|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|response to peptide|
|neuron projection morphogenesis|
|protein localization to membrane|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell-cell adhesion|
|cell part morphogenesis|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|Golgi membrane|
|neuron projection development|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|multi-organism reproductive process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|neuron differentiation|
|organic acid metabolic process|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|mitochondrion|
|locomotion|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|small molecule metabolic process|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.66|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.61|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.38|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.86|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.74|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.99|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|5.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc16a1|SLC16A1]]|0.562|
|[[:human genes:h:hk1|HK1]]|0.441|
|[[:human genes:r:rrm1|RRM1]]|0.423|
|[[:human genes:g:got1|GOT1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1492
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BSG Expression in NALM6 Cells: 8.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>