======= BST1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BST1
  * **<color #00a2e8>Official Name</color>**: bone marrow stromal cell antigen 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=683|683]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q10588|Q10588]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BST1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BST1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600387|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth. {ECO:0000269|PubMed:11866528}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rib hydrolayse|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ADP-ribosyl cyclase activity|
|cyclic ADP-ribose hydrolase|
|NAD+ nucleotidase, cyclic ADP-ribose generating|
|NAD+ nucleosidase activity|
|NAD(P)+ nucleosidase activity|
|phosphorus-oxygen lyase activity|
|uropod|
|regulation of integrin-mediated signaling pathway|
|regulation of neutrophil chemotaxis|
|regulation of cellular extravasation|
|regulation of superoxide metabolic process|
|regulation of neutrophil migration|
|positive regulation of B cell proliferation|
|regulation of granulocyte chemotaxis|
|NAD metabolic process|
|transferase activity|
|regulation of B cell proliferation|
|extrinsic component of membrane|
|specific granule membrane|
|regulation of calcium-mediated signaling|
|anchored component of membrane|
|regulation of leukocyte chemotaxis|
|regulation of cell-matrix adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|positive regulation of B cell activation|
|regulation of reactive oxygen species metabolic process|
|regulation of leukocyte migration|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|regulation of leukocyte proliferation|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of inflammatory response|
|regulation of actin cytoskeleton organization|
|humoral immune response|
|positive regulation of lymphocyte activation|
|regulation of actin filament-based process|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of cytoskeleton organization|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|regulated exocytosis|
|regulation of defense response|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.95|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.83|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.82|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16902
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BST1 Expression in NALM6 Cells: 1.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>