======= BTN2A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BTN2A2
  * **<color #00a2e8>Official Name</color>**: butyrophilin subfamily 2 member A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10385|10385]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WVV5|Q8WVV5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BTN2A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BTN2A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613591|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPRY|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of activated T cell proliferation|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of regulatory T cell differentiation|
|negative regulation of T cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|regulation of regulatory T cell differentiation|
|regulation of activated T cell proliferation|
|regulation of T cell receptor signaling pathway|
|negative regulation of protein kinase B signaling|
|negative regulation of T cell proliferation|
|regulation of antigen receptor-mediated signaling pathway|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of cytokine secretion|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|positive regulation of T cell differentiation|
|positive regulation of lymphocyte differentiation|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|negative regulation of T cell activation|
|regulation of phosphatidylinositol 3-kinase signaling|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of protein secretion|
|regulation of T cell differentiation|
|negative regulation of peptide secretion|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|regulation of G1/S transition of mitotic cell cycle|
|regulation of T cell proliferation|
|regulation of cell cycle G1/S phase transition|
|negative regulation of MAPK cascade|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|T cell receptor signaling pathway|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|negative regulation of mitotic cell cycle phase transition|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|negative regulation of cell cycle phase transition|
|negative regulation of secretion|
|positive regulation of cell-cell adhesion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|regulation of ERK1 and ERK2 cascade|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of mitotic cell cycle|
|regulation of T cell activation|
|negative regulation of cell cycle process|
|signaling receptor binding|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|positive regulation of cell activation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|regulation of protein secretion|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|regulation of mitotic cell cycle|
|activation of immune response|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of secretion|
|positive regulation of immune response|
|positive regulation of cell differentiation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.28|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.88|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17333
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BTN2A2 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>