======= BVES =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BVES
  * **<color #00a2e8>Official Name</color>**: blood vessel epicardial substance
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11149|11149]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NE79|Q8NE79]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BVES&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BVES|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP- binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. {ECO:0000250|UniProtKB:Q5PQZ7, ECO:0000250|UniProtKB:Q9ES83, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:26642364}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Popeye|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sinoatrial node cell development|
|sinoatrial node development|
|sinoatrial node cell differentiation|
|cardiac pacemaker cell development|
|cardiac pacemaker cell differentiation|
|regulation of endocytic recycling|
|cell projection membrane|
|cardiac conduction system development|
|cell migration involved in heart development|
|positive regulation of receptor recycling|
|epithelial cell-cell adhesion|
|cAMP binding|
|regulation of receptor recycling|
|response to ischemia|
|substrate adhesion-dependent cell spreading|
|lateral plasma membrane|
|cardiac muscle cell development|
|vesicle docking|
|cardiac cell development|
|caveola|
|hematopoietic progenitor cell differentiation|
|cardiac muscle cell differentiation|
|regulation of heart rate|
|sarcolemma|
|cardiocyte differentiation|
|bicellular tight junction|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|muscle cell development|
|regulation of cell shape|
|cardiac muscle tissue development|
|organelle localization by membrane tethering|
|membrane docking|
|cell-substrate adhesion|
|structural molecule activity|
|striated muscle cell differentiation|
|regulation of heart contraction|
|muscle cell differentiation|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|regulation of intracellular transport|
|regulation of membrane potential|
|muscle structure development|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|cell-cell adhesion|
|heart development|
|cell junction|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|organelle localization|
|regulation of system process|
|hematopoietic or lymphoid organ development|
|immune system development|
|cell morphogenesis|
|cellular component morphogenesis|
|circulatory system development|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of hydrolase activity|
|locomotion|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|positive regulation of signaling|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16218
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BVES Expression in NALM6 Cells: 4.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>