======= BYSL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BYSL
  * **<color #00a2e8>Official Name</color>**: bystin like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=705|705]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13895|Q13895]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BYSL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BYSL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603871|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. {ECO:0000269|PubMed:17360433, ECO:0000269|PubMed:17381424}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bystin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein localization to nucleolus|
|preribosome, small subunit precursor|
|trophectodermal cell differentiation|
|snoRNA binding|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|blastocyst formation|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|apical part of cell|
|blastocyst development|
|regulation of protein localization to nucleus|
|female pregnancy|
|multi-multicellular organism process|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|in utero embryonic development|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|regulation of cellular protein localization|
|cell population proliferation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|intracellular membrane-bounded organelle|
|nucleolus|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|embryo development|
|multi-organism reproductive process|
|regulation of protein localization|
|RNA binding|
|reproductive process|
|reproduction|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.86|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.73|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.77|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.85|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.86|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.88|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.91|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.18|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|2.19|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.2|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.24|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.29|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|3.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbwd6|CBWD6]]|0.548|
|[[:human genes:c:cbwd5|CBWD5]]|0.546|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.538|
|[[:human genes:c:cbwd3|CBWD3]]|0.536|
|[[:human genes:l:lrr1|LRR1]]|0.517|
|[[:human genes:p:psmb4|PSMB4]]|0.516|
|[[:human genes:t:tceb3c|TCEB3C]]|0.514|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.514|
|[[:human genes:k:kctd17|KCTD17]]|0.506|
|[[:human genes:r:rpl35|RPL35]]|0.504|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.503|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.496|
|[[:human genes:s:sf3a1|SF3A1]]|0.49|
|[[:human genes:g:golga8j|GOLGA8J]]|0.489|
|[[:human genes:p:psmb2|PSMB2]]|0.488|
|[[:human genes:r:rbbp5|RBBP5]]|0.486|
|[[:human genes:r:rps3a|RPS3A]]|0.483|
|[[:human genes:i:igfn1|IGFN1]]|0.482|
|[[:human genes:c:ccna2|CCNA2]]|0.482|
|[[:human genes:c:c14orf93|C14orf93]]|0.48|
|[[:human genes:p:pwp2|PWP2]]|0.48|
|[[:human genes:p:psmb1|PSMB1]]|0.479|
|[[:human genes:r:rps2|RPS2]]|0.476|
|[[:human genes:r:rps5|RPS5]]|0.475|
|[[:human genes:t:tyms|TYMS]]|0.474|
|[[:human genes:t:tspy8|TSPY8]]|0.473|
|[[:human genes:n:npipb5|NPIPB5]]|0.472|
|[[:human genes:r:rps11|RPS11]]|0.471|
|[[:human genes:p:psma7|PSMA7]]|0.471|
|[[:human genes:p:pcf11|PCF11]]|0.47|
|[[:human genes:n:nol10|NOL10]]|0.469|
|[[:human genes:r:rps12|RPS12]]|0.468|
|[[:human genes:p:psmd2|PSMD2]]|0.467|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.466|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.466|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.466|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.466|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.466|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.466|
|[[:human genes:c:copg1|COPG1]]|0.466|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.465|
|[[:human genes:r:rrp7a|RRP7A]]|0.465|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.465|
|[[:human genes:c:chd4|CHD4]]|0.464|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.461|
|[[:human genes:p:psmd3|PSMD3]]|0.459|
|[[:human genes:r:rps19|RPS19]]|0.459|
|[[:human genes:c:copb2|COPB2]]|0.456|
|[[:human genes:o:orc6|ORC6]]|0.456|
|[[:human genes:e:exosc4|EXOSC4]]|0.455|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.455|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.455|
|[[:human genes:s:slc38a7|SLC38A7]]|0.454|
|[[:human genes:o:orc1|ORC1]]|0.454|
|[[:human genes:p:pola1|POLA1]]|0.453|
|[[:human genes:a:ankle2|ANKLE2]]|0.451|
|[[:human genes:s:sf3a3|SF3A3]]|0.451|
|[[:human genes:d:ddtl|DDTL]]|0.451|
|[[:human genes:m:mt1e|MT1E]]|0.45|
|[[:human genes:v:vasn|VASN]]|0.447|
|[[:human genes:t:tfip11|TFIP11]]|0.447|
|[[:human genes:r:rps7|RPS7]]|0.446|
|[[:human genes:b:brix1|BRIX1]]|0.445|
|[[:human genes:e:exosc9|EXOSC9]]|0.443|
|[[:human genes:p:pole|POLE]]|0.442|
|[[:human genes:s:ssh2|SSH2]]|0.441|
|[[:human genes:s:supt5h|SUPT5H]]|0.44|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.44|
|[[:human genes:r:rrp15|RRP15]]|0.439|
|[[:human genes:g:golga8o|GOLGA8O]]|0.439|
|[[:human genes:k:krt78|KRT78]]|0.438|
|[[:human genes:w:wdr75|WDR75]]|0.438|
|[[:human genes:c:cdc6|CDC6]]|0.438|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.438|
|[[:human genes:n:nupl1|NUPL1]]|0.437|
|[[:human genes:n:nup133|NUP133]]|0.436|
|[[:human genes:a:aqr|AQR]]|0.435|
|[[:human genes:c:cdca5|CDCA5]]|0.434|
|[[:human genes:t:ticrr|TICRR]]|0.434|
|[[:human genes:n:ngdn|NGDN]]|0.43|
|[[:human genes:c:ccdc116|CCDC116]]|0.43|
|[[:human genes:p:plk4|PLK4]]|0.43|
|[[:human genes:i:ik|IK]]|0.429|
|[[:human genes:m:myo1h|MYO1H]]|0.428|
|[[:human genes:p:psmd1|PSMD1]]|0.427|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.427|
|[[:human genes:t:twistnb|TWISTNB]]|0.427|
|[[:human genes:d:ddx56|DDX56]]|0.426|
|[[:human genes:r:rrp9|RRP9]]|0.425|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.425|
|[[:human genes:r:rrp12|RRP12]]|0.424|
|[[:human genes:u:utp20|UTP20]]|0.423|
|[[:human genes:p:phf2|PHF2]]|0.421|
|[[:human genes:c:cep192|CEP192]]|0.419|
|[[:human genes:n:nbpf10|NBPF10]]|0.419|
|[[:human genes:f:fam231c|FAM231C]]|0.418|
|[[:human genes:f:fam231a|FAM231A]]|0.418|
|[[:human genes:p:psmd11|PSMD11]]|0.418|
|[[:human genes:p:psmd14|PSMD14]]|0.418|
|[[:human genes:m:mdm2|MDM2]]|0.417|
|[[:human genes:t:terf1|TERF1]]|0.417|
|[[:human genes:s:sart1|SART1]]|0.417|
|[[:human genes:w:wdr46|WDR46]]|0.416|
|[[:human genes:p:polr2f|POLR2F]]|0.416|
|[[:human genes:r:rpl6|RPL6]]|0.416|
|[[:human genes:c:casc3|CASC3]]|0.416|
|[[:human genes:a:arcn1|ARCN1]]|0.416|
|[[:human genes:c:cactin|CACTIN]]|0.415|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.414|
|[[:human genes:p:psma6|PSMA6]]|0.414|
|[[:human genes:e:elmod3|ELMOD3]]|0.413|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.413|
|[[:human genes:r:rnf113a|RNF113A]]|0.412|
|[[:human genes:l:lipe|LIPE]]|0.412|
|[[:human genes:m:myb|MYB]]|0.411|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.411|
|[[:human genes:r:rps9|RPS9]]|0.411|
|[[:human genes:r:rpl34|RPL34]]|0.41|
|[[:human genes:i:incenp|INCENP]]|0.41|
|[[:human genes:a:akirin2|AKIRIN2]]|0.409|
|[[:human genes:p:polr2j3|POLR2J3]]|0.408|
|[[:human genes:d:disp2|DISP2]]|0.407|
|[[:human genes:d:ddx21|DDX21]]|0.407|
|[[:human genes:r:rilpl1|RILPL1]]|0.407|
|[[:human genes:g:golga8k|GOLGA8K]]|0.406|
|[[:human genes:s:sult1a4|SULT1A4]]|0.406|
|[[:human genes:s:sult1a3|SULT1A3]]|0.406|
|[[:human genes:t:tsr1|TSR1]]|0.405|
|[[:human genes:s:slc6a17|SLC6A17]]|0.405|
|[[:human genes:p:pola2|POLA2]]|0.405|
|[[:human genes:z:znf830|ZNF830]]|0.404|
|[[:human genes:x:xab2|XAB2]]|0.404|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.403|
|[[:human genes:p:plekha4|PLEKHA4]]|0.402|
|[[:human genes:a:adrm1|ADRM1]]|0.402|
|[[:human genes:p:polr2h|POLR2H]]|0.402|
|[[:human genes:r:rpl9|RPL9]]|0.402|
|[[:human genes:c:cgb2|CGB2]]|0.4|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.4|
|[[:human genes:r:rad21|RAD21]]|0.4|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 705/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|28/28|
|bone|25/26|
|breast|29/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|0/1|
|gastric|16/16|
|kidney|18/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|14/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BYSL Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>