======= C10orf12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LCOR
  * **<color #00a2e8>Official Name</color>**: ligand dependent nuclear receptor corepressor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84458|84458]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JN0|Q96JN0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C10orf12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C10orf12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607698|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HTH psq|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.2|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.9|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.9|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.77|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.72|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.81|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.84|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.85|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.86|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.89|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.92|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.13|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.15|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.2|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.35|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.35|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.38|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.64|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.74|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5862
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C10ORF12 Expression in NALM6 Cells: 4.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>