======= C11orf30 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EMSY
  * **<color #00a2e8>Official Name</color>**: EMSY transcriptional repressor, BRCA2 interacting
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56946|56946]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z589|Q7Z589]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C11orf30&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C11orf30|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ENT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA repair|
|chromatin organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|protein homodimerization activity|
|chromosome organization|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-2.16|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.16|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.14|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.06|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.97|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.91|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.89|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.87|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.82|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.78|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.77|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.74|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.83|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.84|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.87|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.95|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4762
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C11ORF30 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>