======= C11orf73 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HIKESHI
  * **<color #00a2e8>Official Name</color>**: heat shock protein nuclear import factor hikeshi
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51501|51501]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53FT3|Q53FT3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C11orf73&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C11orf73|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614908|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus. {ECO:0000269|PubMed:22541429}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF775|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear import signal receptor activity|
|Hsp70 protein binding|
|cellular response to heat|
|regulation of cellular response to heat|
|protein import into nucleus|
|response to heat|
|import into nucleus|
|Golgi organization|
|protein import|
|protein localization to nucleus|
|lung development|
|respiratory tube development|
|response to temperature stimulus|
|respiratory system development|
|nucleocytoplasmic transport|
|nuclear transport|
|endomembrane system organization|
|establishment of protein localization to organelle|
|protein localization to organelle|
|regulation of cellular response to stress|
|tube development|
|intracellular protein transport|
|response to abiotic stimulus|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.85|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.74|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.78|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.82|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13003
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C11ORF73 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>