======= C12orf44 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATG101
  * **<color #00a2e8>Official Name</color>**: autophagy related 101
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60673|60673]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSB4|Q9BSB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C12orf44&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C12orf44|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615089|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. {ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:19597335}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1649|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phagophore assembly site|
|autophagosome assembly|
|autophagosome organization|
|vacuole organization|
|macroautophagy|
|regulation of macroautophagy|
|autophagy|
|process utilizing autophagic mechanism|
|protein-containing complex binding|
|regulation of autophagy|
|organelle assembly|
|regulation of cellular catabolic process|
|endoplasmic reticulum membrane|
|regulation of catabolic process|
|identical protein binding|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-3.33|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.78|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.39|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.23|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.95|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.72|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.81|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.86|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wipi2|WIPI2]]|0.55|
|[[:human genes:a:atg9a|ATG9A]]|0.543|
|[[:human genes:r:rb1cc1|RB1CC1]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13255
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C12ORF44 Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>