======= C12orf5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIGAR
  * **<color #00a2e8>Official Name</color>**: TP53 induced glycolysis regulatory phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57103|57103]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQ88|Q9NQ88]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C12orf5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C12orf5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610775|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage (By similarity). Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation (PubMed:23726973). Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions (By similarity). Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1- dependent and p53/TP53-independent manner (PubMed:22887998). Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses (PubMed:25928429). Involved in intestinal tumor progression (PubMed:23726973). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:16839880, ECO:0000269|PubMed:19015259, ECO:0000269|PubMed:19713938, ECO:0000269|PubMed:22887998, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:23726973, ECO:0000269|PubMed:23817040, ECO:0000269|PubMed:25928429}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|His Phos 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of response to DNA integrity checkpoint signaling|
|bisphosphoglycerate 2-phosphatase activity|
|regulation of response to DNA damage checkpoint signaling|
|regulation of response to cell cycle checkpoint signaling|
|regulation of pentose-phosphate shunt|
|negative regulation of NAD metabolic process|
|negative regulation of glucose catabolic process to lactate via pyruvate|
|cellular response to cobalt ion|
|regulation of NADP metabolic process|
|regulation of NAD metabolic process|
|regulation of glucose catabolic process to lactate via pyruvate|
|negative regulation of fermentation|
|fructose 2,6-bisphosphate metabolic process|
|fructose-2,6-bisphosphate 2-phosphatase activity|
|regulation of fermentation|
|positive regulation of hexokinase activity|
|negative regulation of mitophagy|
|negative regulation of autophagy of mitochondrion|
|fructose 1,6-bisphosphate metabolic process|
|response to cobalt ion|
|regulation of cellular carbohydrate catabolic process|
|regulation of hexokinase activity|
|intestinal epithelial cell development|
|positive regulation of cardiac muscle cell apoptotic process|
|negative regulation of glycolytic process|
|regulation of secondary metabolic process|
|positive regulation of striated muscle cell apoptotic process|
|regulation of mitophagy|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|intestinal epithelial cell differentiation|
|negative regulation of ATP metabolic process|
|positive regulation of muscle cell apoptotic process|
|negative regulation of macroautophagy|
|regulation of cardiac muscle cell apoptotic process|
|regulation of striated muscle cell apoptotic process|
|negative regulation of cellular carbohydrate metabolic process|
|regulation of autophagy of mitochondrion|
|negative regulation of carbohydrate metabolic process|
|response to ischemia|
|columnar/cuboidal epithelial cell development|
|negative regulation of mitochondrion organization|
|negative regulation of reactive oxygen species metabolic process|
|response to gamma radiation|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of DNA repair|
|regulation of muscle cell apoptotic process|
|regulation of glycolytic process|
|positive regulation of carbohydrate metabolic process|
|negative regulation of autophagy|
|regulation of carbohydrate catabolic process|
|intracellular|
|negative regulation of small molecule metabolic process|
|columnar/cuboidal epithelial cell differentiation|
|positive regulation of response to DNA damage stimulus|
|regulation of glucose metabolic process|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|regulation of DNA repair|
|digestive tract development|
|regulation of cellular carbohydrate metabolic process|
|digestive system development|
|response to ionizing radiation|
|regulation of generation of precursor metabolites and energy|
|mitochondrial outer membrane|
|regulation of macroautophagy|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|cellular response to hypoxia|
|epithelial cell development|
|cellular response to metal ion|
|positive regulation of DNA metabolic process|
|cellular response to decreased oxygen levels|
|regulation of carbohydrate metabolic process|
|negative regulation of neuron death|
|cellular response to oxygen levels|
|regulation of response to DNA damage stimulus|
|cellular response to inorganic substance|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|response to xenobiotic stimulus|
|dephosphorylation|
|negative regulation of catabolic process|
|regulation of neuron death|
|regulation of autophagy|
|response to hypoxia|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|response to metal ion|
|negative regulation of organelle organization|
|response to oxygen levels|
|regulation of cellular amide metabolic process|
|regulation of small molecule metabolic process|
|response to radiation|
|negative regulation of phosphorylation|
|regulation of response to biotic stimulus|
|response to inorganic substance|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|epithelial cell differentiation|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|tube development|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|regulation of transferase activity|
|negative regulation of cell death|
|regulation of catabolic process|
|carbohydrate derivative metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|cell death|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|cell development|
|regulation of cell death|
|cellular response to stress|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.93|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.568|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14107
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C12ORF5 Expression in NALM6 Cells: 4.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>