======= C12orf65 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C12orf65
  * **<color #00a2e8>Official Name</color>**: chromosome 12 open reading frame 65
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91574|91574]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H3J6|Q9H3J6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C12orf65&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C12orf65|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion. May help rescuing stalled mitoribosomes during translation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RF-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation release factor activity|
|mitochondrial large ribosomal subunit|
|translational termination|
|cellular protein complex disassembly|
|protein-containing complex disassembly|
|translation|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.77|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.76|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.7|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.7|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|1.71|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.74|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.75|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.83|
|[[:results:exp539|42°C R08 exp539]]|1.84|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.87|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.9|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.9|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.9|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.91|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.92|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.99|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.04|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.24|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.28|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.34|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.39|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.46|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.5|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gtpbp10|GTPBP10]]|0.677|
|[[:human genes:r:rpusd4|RPUSD4]]|0.642|
|[[:human genes:n:ndufa3|NDUFA3]]|0.639|
|[[:human genes:m:mrps34|MRPS34]]|0.637|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.637|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.629|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.626|
|[[:human genes:m:mrps16|MRPS16]]|0.625|
|[[:human genes:m:mrps5|MRPS5]]|0.623|
|[[:human genes:m:mrps26|MRPS26]]|0.618|
|[[:human genes:s:selrc1|SELRC1]]|0.613|
|[[:human genes:n:ndufb5|NDUFB5]]|0.612|
|[[:human genes:m:mrpl21|MRPL21]]|0.611|
|[[:human genes:g:gfm1|GFM1]]|0.61|
|[[:human genes:y:yars2|YARS2]]|0.608|
|[[:human genes:m:mrp63|MRP63]]|0.607|
|[[:human genes:n:ndufb11|NDUFB11]]|0.601|
|[[:human genes:m:mrps21|MRPS21]]|0.6|
|[[:human genes:g:gfm2|GFM2]]|0.6|
|[[:human genes:t:tars2|TARS2]]|0.596|
|[[:human genes:m:mrpl23|MRPL23]]|0.594|
|[[:human genes:r:rbfa|RBFA]]|0.593|
|[[:human genes:s:sco2|SCO2]]|0.588|
|[[:human genes:c:cox16|COX16]]|0.585|
|[[:human genes:c:c17orf89|C17orf89]]|0.583|
|[[:human genes:m:mrpl53|MRPL53]]|0.579|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.578|
|[[:human genes:f:fastkd5|FASTKD5]]|0.576|
|[[:human genes:q:qrsl1|QRSL1]]|0.575|
|[[:human genes:p:polg|POLG]]|0.569|
|[[:human genes:p:pdss1|PDSS1]]|0.562|
|[[:human genes:l:lars2|LARS2]]|0.562|
|[[:human genes:m:mrps6|MRPS6]]|0.562|
|[[:human genes:c:coq2|COQ2]]|0.561|
|[[:human genes:e:ears2|EARS2]]|0.56|
|[[:human genes:m:mrps11|MRPS11]]|0.559|
|[[:human genes:m:mrps14|MRPS14]]|0.559|
|[[:human genes:s:slc25a26|SLC25A26]]|0.558|
|[[:human genes:d:dars2|DARS2]]|0.558|
|[[:human genes:n:ndufc2|NDUFC2]]|0.555|
|[[:human genes:v:vars2|VARS2]]|0.555|
|[[:human genes:f:ftsj2|FTSJ2]]|0.554|
|[[:human genes:n:ndufa2|NDUFA2]]|0.552|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.549|
|[[:human genes:a:aifm1|AIFM1]]|0.549|
|[[:human genes:m:mrpl55|MRPL55]]|0.546|
|[[:human genes:c:coa6|COA6]]|0.545|
|[[:human genes:m:mtg2|MTG2]]|0.544|
|[[:human genes:r:rars2|RARS2]]|0.541|
|[[:human genes:m:mipep|MIPEP]]|0.541|
|[[:human genes:b:bcs1l|BCS1L]]|0.54|
|[[:human genes:r:rpusd3|RPUSD3]]|0.537|
|[[:human genes:m:mto1|MTO1]]|0.535|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.534|
|[[:human genes:s:sars2|SARS2]]|0.534|
|[[:human genes:m:mrpl45|MRPL45]]|0.532|
|[[:human genes:c:cox15|COX15]]|0.532|
|[[:human genes:m:mrpl47|MRPL47]]|0.532|
|[[:human genes:m:mcat|MCAT]]|0.532|
|[[:human genes:t:timm8b|TIMM8B]]|0.529|
|[[:human genes:p:pnpt1|PNPT1]]|0.529|
|[[:human genes:m:mrps25|MRPS25]]|0.528|
|[[:human genes:n:nars2|NARS2]]|0.527|
|[[:human genes:e:ecsit|ECSIT]]|0.525|
|[[:human genes:m:mrps24|MRPS24]]|0.524|
|[[:human genes:w:wbscr16|WBSCR16]]|0.524|
|[[:human genes:p:polg2|POLG2]]|0.524|
|[[:human genes:m:mettl17|METTL17]]|0.523|
|[[:human genes:g:gatc|GATC]]|0.523|
|[[:human genes:t:tefm|TEFM]]|0.523|
|[[:human genes:n:ndufs2|NDUFS2]]|0.522|
|[[:human genes:m:mrps18a|MRPS18A]]|0.522|
|[[:human genes:c:coa3|COA3]]|0.521|
|[[:human genes:m:mrps10|MRPS10]]|0.52|
|[[:human genes:p:pars2|PARS2]]|0.52|
|[[:human genes:n:nfu1|NFU1]]|0.517|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.515|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.513|
|[[:human genes:m:mrpl20|MRPL20]]|0.51|
|[[:human genes:c:cox6c|COX6C]]|0.509|
|[[:human genes:m:mtif3|MTIF3]]|0.509|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.508|
|[[:human genes:m:mrps33|MRPS33]]|0.506|
|[[:human genes:m:mrpl15|MRPL15]]|0.504|
|[[:human genes:t:tmem126b|TMEM126B]]|0.502|
|[[:human genes:p:pet112|PET112]]|0.502|
|[[:human genes:i:iba57|IBA57]]|0.502|
|[[:human genes:m:mrps9|MRPS9]]|0.501|
|[[:human genes:c:chchd1|CHCHD1]]|0.501|
|[[:human genes:d:dap3|DAP3]]|0.499|
|[[:human genes:p:pet117|PET117]]|0.497|
|[[:human genes:n:ndufa1|NDUFA1]]|0.497|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.497|
|[[:human genes:m:mrps23|MRPS23]]|0.496|
|[[:human genes:c:c10orf2|C10orf2]]|0.495|
|[[:human genes:a:atp5sl|ATP5SL]]|0.495|
|[[:human genes:g:grsf1|GRSF1]]|0.493|
|[[:human genes:f:fastkd2|FASTKD2]]|0.492|
|[[:human genes:m:mtpap|MTPAP]]|0.492|
|[[:human genes:m:mtg1|MTG1]]|0.491|
|[[:human genes:m:mrpl12|MRPL12]]|0.489|
|[[:human genes:c:clpp|CLPP]]|0.489|
|[[:human genes:t:tufm|TUFM]]|0.489|
|[[:human genes:s:ssbp1|SSBP1]]|0.486|
|[[:human genes:t:tmem242|TMEM242]]|0.484|
|[[:human genes:c:coq7|COQ7]]|0.484|
|[[:human genes:m:mrpl11|MRPL11]]|0.483|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.482|
|[[:human genes:n:nubpl|NUBPL]]|0.48|
|[[:human genes:a:acad9|ACAD9]]|0.48|
|[[:human genes:n:ndufa11|NDUFA11]]|0.479|
|[[:human genes:t:trub2|TRUB2]]|0.479|
|[[:human genes:n:ndufb6|NDUFB6]]|0.478|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.478|
|[[:human genes:t:tomm6|TOMM6]]|0.478|
|[[:human genes:m:mrpl22|MRPL22]]|0.475|
|[[:human genes:f:foxred1|FOXRED1]]|0.474|
|[[:human genes:f:fars2|FARS2]]|0.473|
|[[:human genes:i:isca2|ISCA2]]|0.472|
|[[:human genes:c:coq3|COQ3]]|0.472|
|[[:human genes:n:ndufs7|NDUFS7]]|0.471|
|[[:human genes:t:tomm20|TOMM20]]|0.47|
|[[:human genes:c:chchd4|CHCHD4]]|0.47|
|[[:human genes:a:aars2|AARS2]]|0.469|
|[[:human genes:m:mars2|MARS2]]|0.469|
|[[:human genes:t:tmem261|TMEM261]]|0.469|
|[[:human genes:g:glrx5|GLRX5]]|0.467|
|[[:human genes:n:ndufb9|NDUFB9]]|0.466|
|[[:human genes:a:alkbh1|ALKBH1]]|0.465|
|[[:human genes:n:noa1|NOA1]]|0.463|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.463|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.462|
|[[:human genes:h:hars2|HARS2]]|0.462|
|[[:human genes:n:ndufb3|NDUFB3]]|0.461|
|[[:human genes:l:lsm10|LSM10]]|0.46|
|[[:human genes:m:mrps12|MRPS12]]|0.46|
|[[:human genes:t:tomm40|TOMM40]]|0.46|
|[[:human genes:n:ndufv1|NDUFV1]]|0.459|
|[[:human genes:m:mrps17|MRPS17]]|0.458|
|[[:human genes:m:mrpl44|MRPL44]]|0.456|
|[[:human genes:n:ndufb1|NDUFB1]]|0.455|
|[[:human genes:p:pitrm1|PITRM1]]|0.454|
|[[:human genes:d:dhrsx|DHRSX]]|0.454|
|[[:human genes:t:tfb1m|TFB1M]]|0.453|
|[[:human genes:d:ddx28|DDX28]]|0.453|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.452|
|[[:human genes:d:dhx30|DHX30]]|0.449|
|[[:human genes:m:mrps2|MRPS2]]|0.449|
|[[:human genes:a:angel2|ANGEL2]]|0.449|
|[[:human genes:m:malsu1|MALSU1]]|0.446|
|[[:human genes:m:mrps27|MRPS27]]|0.445|
|[[:human genes:n:ndufa8|NDUFA8]]|0.444|
|[[:human genes:c:cars2|CARS2]]|0.444|
|[[:human genes:n:ndufa6|NDUFA6]]|0.443|
|[[:human genes:p:polrmt|POLRMT]]|0.443|
|[[:human genes:w:wars2|WARS2]]|0.441|
|[[:human genes:m:mrpl43|MRPL43]]|0.441|
|[[:human genes:u:uqcrq|UQCRQ]]|0.44|
|[[:human genes:t:triap1|TRIAP1]]|0.439|
|[[:human genes:c:cox7b|COX7B]]|0.438|
|[[:human genes:t:tpk1|TPK1]]|0.435|
|[[:human genes:m:minos1|MINOS1]]|0.435|
|[[:human genes:f:fh|FH]]|0.434|
|[[:human genes:f:fastkd1|FASTKD1]]|0.433|
|[[:human genes:m:mrpl1|MRPL1]]|0.432|
|[[:human genes:h:higd2a|HIGD2A]]|0.429|
|[[:human genes:m:mrpl4|MRPL4]]|0.428|
|[[:human genes:m:mrps7|MRPS7]]|0.427|
|[[:human genes:d:dnlz|DNLZ]]|0.427|
|[[:human genes:a:atp5c1|ATP5C1]]|0.426|
|[[:human genes:c:cox17|COX17]]|0.425|
|[[:human genes:m:mrps35|MRPS35]]|0.425|
|[[:human genes:n:ndufs8|NDUFS8]]|0.423|
|[[:human genes:n:ndufs5|NDUFS5]]|0.423|
|[[:human genes:m:mterfd2|MTERFD2]]|0.422|
|[[:human genes:g:gemin7|GEMIN7]]|0.422|
|[[:human genes:c:cox11|COX11]]|0.422|
|[[:human genes:p:pgm3|PGM3]]|0.421|
|[[:human genes:n:ndufb7|NDUFB7]]|0.421|
|[[:human genes:e:elac2|ELAC2]]|0.42|
|[[:human genes:c:coq4|COQ4]]|0.42|
|[[:human genes:m:mrpl46|MRPL46]]|0.419|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.418|
|[[:human genes:t:tomm22|TOMM22]]|0.418|
|[[:human genes:m:mtif2|MTIF2]]|0.418|
|[[:human genes:n:ndufa10|NDUFA10]]|0.417|
|[[:human genes:m:mrpl17|MRPL17]]|0.416|
|[[:human genes:m:mrpl42|MRPL42]]|0.412|
|[[:human genes:l:lrpprc|LRPPRC]]|0.412|
|[[:human genes:n:ndufb2|NDUFB2]]|0.411|
|[[:human genes:m:mtrf1|MTRF1]]|0.41|
|[[:human genes:m:mrpl36|MRPL36]]|0.409|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.407|
|[[:human genes:c:coq6|COQ6]]|0.407|
|[[:human genes:m:mrpl34|MRPL34]]|0.406|
|[[:human genes:t:timm17a|TIMM17A]]|0.406|
|[[:human genes:c:cox5a|COX5A]]|0.405|
|[[:human genes:m:mrpl41|MRPL41]]|0.405|
|[[:human genes:p:ptcd3|PTCD3]]|0.401|
|[[:human genes:a:atp5a1|ATP5A1]]|0.401|
|[[:human genes:c:cox6b1|COX6B1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2617
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C12orf65 Expression in NALM6 Cells: 9.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>