======= C14orf80 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TEDC1
  * **<color #00a2e8>Official Name</color>**: tubulin epsilon and delta complex 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283643|283643]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86SX3|Q86SX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C14orf80&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C14orf80|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F. {ECO:0000269|PubMed:28796488}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.24|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.9|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.8|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.79|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.77|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.71|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.71|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.88|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.91|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.94|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|5.15|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|5.28|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|6.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c16orf59|C16orf59]]|0.799|
|[[:human genes:t:tubd1|TUBD1]]|0.788|
|[[:human genes:t:tube1|TUBE1]]|0.718|
|[[:human genes:c:cep120|CEP120]]|0.679|
|[[:human genes:p:pidd|PIDD]]|0.637|
|[[:human genes:o:odf2|ODF2]]|0.633|
|[[:human genes:c:cep44|CEP44]]|0.622|
|[[:human genes:c:c2cd3|C2CD3]]|0.62|
|[[:human genes:p:pibf1|PIBF1]]|0.599|
|[[:human genes:c:casp2|CASP2]]|0.598|
|[[:human genes:c:cradd|CRADD]]|0.594|
|[[:human genes:o:ofd1|OFD1]]|0.559|
|[[:human genes:r:rttn|RTTN]]|0.559|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.55|
|[[:human genes:b:bub3|BUB3]]|0.541|
|[[:human genes:c:ccdc41|CCDC41]]|0.541|
|[[:human genes:a:ankrd26|ANKRD26]]|0.535|
|[[:human genes:s:sclt1|SCLT1]]|0.533|
|[[:human genes:n:nin|NIN]]|0.508|
|[[:human genes:s:srp14|SRP14]]|0.498|
|[[:human genes:u:urm1|URM1]]|0.483|
|[[:human genes:g:gemin8|GEMIN8]]|0.478|
|[[:human genes:t:thg1l|THG1L]]|0.478|
|[[:human genes:c:cep76|CEP76]]|0.474|
|[[:human genes:n:n6amt1|N6AMT1]]|0.474|
|[[:human genes:c:cep128|CEP128]]|0.464|
|[[:human genes:c:cenpa|CENPA]]|0.464|
|[[:human genes:e:elp3|ELP3]]|0.463|
|[[:human genes:f:fopnl|FOPNL]]|0.462|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.455|
|[[:human genes:c:cep152|CEP152]]|0.452|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.451|
|[[:human genes:w:wdr1|WDR1]]|0.451|
|[[:human genes:t:tkt|TKT]]|0.451|
|[[:human genes:d:dnajb6|DNAJB6]]|0.44|
|[[:human genes:f:fntb|FNTB]]|0.44|
|[[:human genes:t:tsen54|TSEN54]]|0.439|
|[[:human genes:s:srp9|SRP9]]|0.436|
|[[:human genes:a:atxn10|ATXN10]]|0.432|
|[[:human genes:f:fbxw7|FBXW7]]|0.431|
|[[:human genes:h:hyls1|HYLS1]]|0.43|
|[[:human genes:k:kdm8|KDM8]]|0.429|
|[[:human genes:r:rpp21|RPP21]]|0.429|
|[[:human genes:n:nsmce1|NSMCE1]]|0.429|
|[[:human genes:k:kiaa0586|KIAA0586]]|0.427|
|[[:human genes:h:hspa4|HSPA4]]|0.427|
|[[:human genes:c:cep78|CEP78]]|0.424|
|[[:human genes:d:ddx42|DDX42]]|0.424|
|[[:human genes:d:dpagt1|DPAGT1]]|0.417|
|[[:human genes:n:nhlrc2|NHLRC2]]|0.41|
|[[:human genes:g:gemin6|GEMIN6]]|0.408|
|[[:human genes:p:pfn1|PFN1]]|0.406|
|[[:human genes:u:uap1|UAP1]]|0.404|
|[[:human genes:a:alg1|ALG1]]|0.403|
|[[:human genes:t:tbca|TBCA]]|0.403|
|[[:human genes:a:atic|ATIC]]|0.401|
|[[:human genes:i:ipp|IPP]]|0.4|
|[[:human genes:r:rbbp4|RBBP4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 53/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|2/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|4/21|
|liver|3/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 777
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C14ORF80 Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>