======= C17orf70 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAAP100
  * **<color #00a2e8>Official Name</color>**: FA core complex associated protein 100
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80233|80233]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q0VG06|Q0VG06]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C17orf70&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C17orf70|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611301|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. {ECO:0000269|PubMed:17396147}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Fanconi anaemia nuclear complex|
|intermediate filament cytoskeleton|
|interstrand cross-link repair|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|DNA binding|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.51|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.44|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.29|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.83|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.74|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.71|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fance|FANCE]]|0.57|
|[[:human genes:f:fancb|FANCB]]|0.538|
|[[:human genes:f:fancc|FANCC]]|0.511|
|[[:human genes:f:fanca|FANCA]]|0.51|
|[[:human genes:f:fancd2|FANCD2]]|0.497|
|[[:human genes:e:ercc1|ERCC1]]|0.475|
|[[:human genes:b:brip1|BRIP1]]|0.468|
|[[:human genes:f:fancg|FANCG]]|0.438|
|[[:human genes:f:fancl|FANCL]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 474
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C17ORF70 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>