======= C1orf27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ODR4
  * **<color #00a2e8>Official Name</color>**: odr-4 GPCR localization factor homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54953|54953]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5SWX8|Q5SWX8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C1orf27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C1orf27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609335|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the trafficking of a subset of G- protein coupled receptors. {ECO:0000250|UniProtKB:Q8I7F8}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.97|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.8|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.3|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.15|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.15|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.92|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.92|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.86|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.84|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.73|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.74|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.77|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.86|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.9|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.94|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.1|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.29|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ufsp2|UFSP2]]|0.771|
|[[:human genes:u:ufc1|UFC1]]|0.767|
|[[:human genes:u:uba5|UBA5]]|0.748|
|[[:human genes:u:ufm1|UFM1]]|0.745|
|[[:human genes:u:ufl1|UFL1]]|0.667|
|[[:human genes:d:ddrgk1|DDRGK1]]|0.596|
|[[:human genes:a:alg6|ALG6]]|0.529|
|[[:human genes:u:ube2j1|UBE2J1]]|0.526|
|[[:human genes:t:tmed10|TMED10]]|0.509|
|[[:human genes:d:dnajb11|DNAJB11]]|0.506|
|[[:human genes:s:sbds|SBDS]]|0.496|
|[[:human genes:d:dnajc3|DNAJC3]]|0.487|
|[[:human genes:a:atp5o|ATP5O]]|0.461|
|[[:human genes:a:alg8|ALG8]]|0.46|
|[[:human genes:u:ube2g2|UBE2G2]]|0.455|
|[[:human genes:s:sec62|SEC62]]|0.452|
|[[:human genes:m:manf|MANF]]|0.449|
|[[:human genes:a:asb7|ASB7]]|0.437|
|[[:human genes:a:atp5b|ATP5B]]|0.436|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.431|
|[[:human genes:a:alg5|ALG5]]|0.428|
|[[:human genes:a:atp5a1|ATP5A1]]|0.422|
|[[:human genes:e:eif1ax|EIF1AX]]|0.417|
|[[:human genes:d:derl1|DERL1]]|0.415|
|[[:human genes:d:derl2|DERL2]]|0.41|
|[[:human genes:e:eftud1|EFTUD1]]|0.407|
|[[:human genes:a:alg1|ALG1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C1ORF27 Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>