======= C2CD2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C2CD2L
  * **<color #00a2e8>Official Name</color>**: C2CD2 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9854|9854]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14523|O14523]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C2CD2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C2CD2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617582|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5- bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (PubMed:28209843). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (PubMed:28209843). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers (PubMed:28209843). In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C- terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane (PubMed:28209843). Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules (PubMed:28209843). {ECO:0000269|PubMed:28209843}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of apical plasma membrane|
|insulin binding|
|cortical endoplasmic reticulum|
|phosphatidylinositol transfer activity|
|endoplasmic reticulum-plasma membrane contact site|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of insulin secretion|
|phosphatidylinositol binding|
|phospholipid transport|
|positive regulation of peptide hormone secretion|
|organophosphate ester transport|
|positive regulation of hormone secretion|
|regulation of insulin secretion|
|regulation of peptide hormone secretion|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|lipid transport|
|lipid localization|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|organic anion transport|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of hormone levels|
|anion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|regulation of protein localization|
|ion transport|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.93|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.73|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.71|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.8|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.03|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:smarce1|SMARCE1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5852
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C2CD2L Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>