======= C2orf48 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RRM2
  * **<color #00a2e8>Official Name</color>**: ribonucleotide reductase regulatory subunit M2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6241|6241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31350|P31350]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C2orf48&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C2orf48|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribonuc red sm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonucleoside-diphosphate reductase complex|
|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|
|ferric iron binding|
|deoxyribonucleotide biosynthetic process|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|nucleobase-containing small molecule interconversion|
|protein heterotetramerization|
|deoxyribonucleotide metabolic process|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|protein heterooligomerization|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|protein tetramerization|
|DNA replication|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|negative regulation of cell cycle process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|protein complex oligomerization|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|carbohydrate derivative biosynthetic process|
|mitotic cell cycle|
|regulation of cell cycle process|
|protein homodimerization activity|
|organophosphate metabolic process|
|oxidation-reduction process|
|cell cycle process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|organic cyclic compound biosynthetic process|
|cell cycle|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.78|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 737/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12977
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C2ORF48 Expression in NALM6 Cells: 2.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>