======= C4BPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C4BPB
  * **<color #00a2e8>Official Name</color>**: complement component 4 binding protein beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=725|725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20851|P20851]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C4BPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C4BPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120831|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of complement activation, classical pathway|
|regulation of opsonization|
|regulation of complement activation, classical pathway|
|response to symbiont|
|response to symbiotic bacterium|
|negative regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of complement activation|
|negative regulation of immunoglobulin mediated immune response|
|negative regulation of B cell mediated immunity|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of humoral immune response|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte mediated immunity|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of phagocytosis|
|regulation of complement activation|
|negative regulation of immune effector process|
|regulation of humoral immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|positive regulation of protein catabolic process|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|blood coagulation|
|coagulation|
|hemostasis|
|humoral immune response|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|regulation of immune effector process|
|wound healing|
|regulation of body fluid levels|
|regulation of vesicle-mediated transport|
|response to wounding|
|adaptive immune response|
|activation of immune response|
|response to bacterium|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of immune response|
|defense response to other organism|
|regulation of catabolic process|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11650
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C4BPB Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>