======= C7orf76 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEM1
  * **<color #00a2e8>Official Name</color>**: SEM1 26S proteasome complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7979|7979]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"P60896|Q6ZVN7"|"P60896|Q6ZVN7"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C7orf76&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C7orf76|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proteasome regulatory particle, lid subcomplex|
|proteasome assembly|
|double-strand break repair via homologous recombination|
|recombinational repair|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|double-strand break repair|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|DNA recombination|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.96|
|[[:results:exp136|MS094 2μM R03 exp136]]|-1.92|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.86|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.76|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 330/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|19/28|
|blood|13/28|
|bone|10/26|
|breast|16/33|
|central nervous system|32/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|8/16|
|kidney|6/21|
|liver|10/20|
|lung|29/75|
|lymphocyte|10/16|
|ovary|12/26|
|pancreas|6/24|
|peripheral nervous system|7/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15489
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C7ORF76 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>