======= CA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CA2
  * **<color #00a2e8>Official Name</color>**: carbonic anhydrase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=760|760]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00918|P00918]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. {ECO:0000250, ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:15990874}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Carb anhydrase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of dipeptide transmembrane transport|
|positive regulation of dipeptide transmembrane transport|
|regulation of dipeptide transport|
|positive regulation of dipeptide transport|
|positive regulation of oligopeptide transport|
|regulation of oligopeptide transport|
|carbon dioxide transport|
|positive regulation of cellular pH reduction|
|regulation of cellular pH reduction|
|arylesterase activity|
|angiotensin-activated signaling pathway|
|regulation of chloride transport|
|positive regulation of synaptic transmission, GABAergic|
|one-carbon compound transport|
|carbonate dehydratase activity|
|cellular response to fluid shear stress|
|positive regulation of bone remodeling|
|gas transport|
|positive regulation of bone resorption|
|cellular response to angiotensin|
|positive regulation of osteoclast differentiation|
|response to angiotensin|
|myelin sheath|
|positive regulation of tissue remodeling|
|regulation of synaptic transmission, GABAergic|
|response to fluid shear stress|
|regulation of bone resorption|
|response to pH|
|bicarbonate transport|
|regulation of bone remodeling|
|response to zinc ion|
|positive regulation of myeloid leukocyte differentiation|
|microvillus|
|regulation of osteoclast differentiation|
|apical part of cell|
|regulation of tissue remodeling|
|response to estrogen|
|odontogenesis of dentin-containing tooth|
|regulation of intracellular pH|
|regulation of cellular pH|
|positive regulation of myeloid cell differentiation|
|regulation of anion transport|
|regulation of pH|
|cellular monovalent inorganic cation homeostasis|
|regulation of myeloid leukocyte differentiation|
|odontogenesis|
|monovalent inorganic cation homeostasis|
|positive regulation of leukocyte differentiation|
|drug transport|
|positive regulation of synaptic transmission|
|positive regulation of hemopoiesis|
|basolateral plasma membrane|
|positive regulation of transmembrane transport|
|regulation of myeloid cell differentiation|
|cellular response to peptide hormone stimulus|
|kidney development|
|regulation of leukocyte differentiation|
|renal system development|
|axon|
|urogenital system development|
|cellular response to peptide|
|response to steroid hormone|
|response to metal ion|
|response to peptide hormone|
|morphogenesis of an epithelium|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of hemopoiesis|
|organic anion transport|
|response to peptide|
|response to inorganic substance|
|regulation of transmembrane transport|
|tissue morphogenesis|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|ion homeostasis|
|zinc ion binding|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|epithelium development|
|secretion|
|positive regulation of immune system process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8149
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CA2 Expression in NALM6 Cells: 1.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>