======= CAB39 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAB39
  * **<color #00a2e8>Official Name</color>**: calcium binding protein 39
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51719|51719]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y376|Q9Y376]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAB39&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAB39|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612174|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. {ECO:0000269|PubMed:19892943}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mo25|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serine/threonine protein kinase complex|
|cellular hypotonic response|
|hypotonic response|
|negative regulation of potassium ion transmembrane transporter activity|
|negative regulation of potassium ion transmembrane transport|
|protein kinase activator activity|
|protein serine/threonine kinase activator activity|
|positive regulation of peptidyl-threonine phosphorylation|
|negative regulation of potassium ion transport|
|cellular response to osmotic stress|
|regulation of peptidyl-threonine phosphorylation|
|regulation of potassium ion transmembrane transporter activity|
|negative regulation of ion transmembrane transporter activity|
|response to osmotic stress|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|kinase binding|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|protein heterooligomerization|
|secretory granule lumen|
|negative regulation of transmembrane transport|
|ficolin-1-rich granule lumen|
|cell cycle arrest|
|negative regulation of ion transport|
|peptidyl-serine phosphorylation|
|peptidyl-serine modification|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|activation of protein kinase activity|
|regulation of cation transmembrane transport|
|positive regulation of protein serine/threonine kinase activity|
|protein serine/threonine kinase activity|
|regulation of metal ion transport|
|signal transduction by protein phosphorylation|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|regulation of transmembrane transport|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of transferase activity|
|regulation of ion transport|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|cell cycle process|
|secretion by cell|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.09|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.77|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.74|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.78|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.78|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.11|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.15|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|2.24|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1652
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAB39 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>