======= CACNG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNG2
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel auxiliary subunit gamma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10369|10369]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y698|Q9Y698]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602911|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:20805473}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein localization to basolateral plasma membrane|
|eye blink reflex|
|positive regulation of protein localization to basolateral plasma membrane|
|cerebellar mossy fiber|
|neurotransmitter receptor transport, postsynaptic endosome to lysosome|
|positive regulation of AMPA receptor activity|
|channel regulator activity|
|receptor diffusion trapping|
|membrane hyperpolarization|
|neurotransmitter receptor diffusion trapping|
|postsynaptic neurotransmitter receptor diffusion trapping|
|somatodendritic compartment|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|neurotransmitter receptor internalization|
|protein localization to postsynaptic specialization membrane|
|positive regulation of glutamate receptor signaling pathway|
|reflex|
|postsynaptic density membrane|
|regulation of AMPA receptor activity|
|voltage-gated calcium channel complex|
|AMPA glutamate receptor complex|
|positive regulation of synaptic transmission, glutamatergic|
|ionotropic glutamate receptor binding|
|neurotransmitter receptor transport|
|positive regulation of signaling receptor activity|
|hippocampal mossy fiber to CA3 synapse|
|protein localization to postsynaptic membrane|
|protein localization to lysosome|
|voltage-gated calcium channel activity|
|receptor localization to synapse|
|neuromuscular junction development|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment of protein localization to vacuole|
|integral component of postsynaptic density membrane|
|membrane depolarization|
|transmission of nerve impulse|
|receptor internalization|
|protein localization to vacuole|
|positive regulation of protein localization to cell periphery|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|endocytic vesicle membrane|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of cation channel activity|
|regulation of neurotransmitter receptor activity|
|Schaffer collateral - CA1 synapse|
|localization within membrane|
|cardiac conduction|
|positive regulation of ion transmembrane transporter activity|
|receptor metabolic process|
|lysosomal transport|
|positive regulation of transporter activity|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|multicellular organismal signaling|
|vacuolar transport|
|positive regulation of cation transmembrane transport|
|positive regulation of synaptic transmission|
|response to calcium ion|
|positive regulation of ion transmembrane transport|
|protein targeting to membrane|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of protein localization to membrane|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|regulation of heart contraction|
|calcium ion transport|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|establishment of protein localization to membrane|
|regulation of transmembrane transporter activity|
|synapse organization|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|protein targeting|
|response to metal ion|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|response to inorganic substance|
|regulation of cellular protein localization|
|cell junction|
|endocytosis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|protein localization to organelle|
|cation transport|
|regulation of cellular localization|
|ion transmembrane transport|
|positive regulation of transport|
|intracellular protein transport|
|regulation of protein localization|
|transmembrane transport|
|ion transport|
|nervous system process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11987
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNG2 Expression in NALM6 Cells: -0.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>