======= CACTIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACTIN
  * **<color #00a2e8>Official Name</color>**: cactin, spliceosome C complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58509|58509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUQ7|Q8WUQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACTIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACTIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618536|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing. {ECO:0000269|PubMed:20829348}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CactinC cactus|
|Cactin mid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of lipopolysaccharide-mediated signaling pathway|
|negative regulation of type I interferon-mediated signaling pathway|
|negative regulation of interferon-beta production|
|negative regulation of interleukin-8 production|
|regulation of lipopolysaccharide-mediated signaling pathway|
|regulation of type I interferon-mediated signaling pathway|
|negative regulation of toll-like receptor signaling pathway|
|negative regulation of type I interferon production|
|regulation of interferon-beta production|
|negative regulation of innate immune response|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|regulation of toll-like receptor signaling pathway|
|regulation of interleukin-8 production|
|negative regulation of NF-kappaB transcription factor activity|
|catalytic step 2 spliceosome|
|negative regulation of response to biotic stimulus|
|regulation of type I interferon production|
|negative regulation of immune response|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of DNA-binding transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|cellular response to interleukin-1|
|regulation of response to cytokine stimulus|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|negative regulation of defense response|
|cellular response to biotic stimulus|
|negative regulation of multi-organism process|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|negative regulation of cytokine production|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|negative regulation of response to external stimulus|
|RNA splicing|
|nuclear speck|
|negative regulation of protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of innate immune response|
|mRNA processing|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|response to bacterium|
|mRNA metabolic process|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|response to lipid|
|RNA processing|
|defense response to other organism|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|response to cytokine|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|RNA binding|
|regulation of protein phosphorylation|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.87|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.79|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.82|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.9|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl35|RPL35]]|0.572|
|[[:human genes:t:tceb3c|TCEB3C]]|0.572|
|[[:human genes:p:psmb4|PSMB4]]|0.557|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.548|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.547|
|[[:human genes:n:narfl|NARFL]]|0.543|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.531|
|[[:human genes:c:chd4|CHD4]]|0.526|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.523|
|[[:human genes:r:rps2|RPS2]]|0.518|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.514|
|[[:human genes:p:psma6|PSMA6]]|0.514|
|[[:human genes:a:aqr|AQR]]|0.514|
|[[:human genes:s:supt5h|SUPT5H]]|0.502|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.502|
|[[:human genes:n:nupl1|NUPL1]]|0.501|
|[[:human genes:i:itga2b|ITGA2B]]|0.5|
|[[:human genes:d:ddtl|DDTL]]|0.498|
|[[:human genes:c:col2a1|COL2A1]]|0.493|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.492|
|[[:human genes:t:tfip11|TFIP11]]|0.491|
|[[:human genes:k:kctd17|KCTD17]]|0.49|
|[[:human genes:c:cdc6|CDC6]]|0.489|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.487|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.487|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.487|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.487|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.487|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.487|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.486|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.486|
|[[:human genes:a:acsf2|ACSF2]]|0.483|
|[[:human genes:p:psmb2|PSMB2]]|0.483|
|[[:human genes:r:rrp15|RRP15]]|0.479|
|[[:human genes:o:orc1|ORC1]]|0.477|
|[[:human genes:n:napa|NAPA]]|0.477|
|[[:human genes:t:tspy2|TSPY2]]|0.475|
|[[:human genes:n:nup43|NUP43]]|0.475|
|[[:human genes:c:copg1|COPG1]]|0.473|
|[[:human genes:s:slc4a1|SLC4A1]]|0.472|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.472|
|[[:human genes:c:copb1|COPB1]]|0.471|
|[[:human genes:r:rad51|RAD51]]|0.471|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.471|
|[[:human genes:z:znf830|ZNF830]]|0.47|
|[[:human genes:m:mt1e|MT1E]]|0.47|
|[[:human genes:r:rps12|RPS12]]|0.47|
|[[:human genes:c:cebpz|CEBPZ]]|0.47|
|[[:human genes:i:iscu|ISCU]]|0.47|
|[[:human genes:p:ppie|PPIE]]|0.469|
|[[:human genes:r:rnf113a|RNF113A]]|0.469|
|[[:human genes:p:psmb1|PSMB1]]|0.468|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.467|
|[[:human genes:n:nuf2|NUF2]]|0.465|
|[[:human genes:p:psmc1|PSMC1]]|0.465|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.464|
|[[:human genes:c:chaf1a|CHAF1A]]|0.462|
|[[:human genes:l:lrr1|LRR1]]|0.461|
|[[:human genes:a:ankle2|ANKLE2]]|0.46|
|[[:human genes:c:cbwd3|CBWD3]]|0.46|
|[[:human genes:p:psmc2|PSMC2]]|0.459|
|[[:human genes:a:ankle1|ANKLE1]]|0.459|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.458|
|[[:human genes:z:zfand5|ZFAND5]]|0.457|
|[[:human genes:t:tyms|TYMS]]|0.457|
|[[:human genes:o:osbp|OSBP]]|0.457|
|[[:human genes:f:fam25b|FAM25B]]|0.457|
|[[:human genes:r:rpl6|RPL6]]|0.456|
|[[:human genes:p:pwp2|PWP2]]|0.454|
|[[:human genes:t:tspy1|TSPY1]]|0.453|
|[[:human genes:u:utp3|UTP3]]|0.453|
|[[:human genes:d:dhx38|DHX38]]|0.453|
|[[:human genes:n:nbpf10|NBPF10]]|0.452|
|[[:human genes:m:med14|MED14]]|0.451|
|[[:human genes:r:rpl38|RPL38]]|0.451|
|[[:human genes:f:fam160a1|FAM160A1]]|0.451|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.449|
|[[:human genes:h:hap1|HAP1]]|0.448|
|[[:human genes:s:syt9|SYT9]]|0.448|
|[[:human genes:r:ranbp2|RANBP2]]|0.448|
|[[:human genes:m:myb|MYB]]|0.448|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.448|
|[[:human genes:e:exosc8|EXOSC8]]|0.448|
|[[:human genes:g:golga8o|GOLGA8O]]|0.447|
|[[:human genes:r:rpl34|RPL34]]|0.447|
|[[:human genes:a:aatf|AATF]]|0.447|
|[[:human genes:k:krt78|KRT78]]|0.446|
|[[:human genes:c:cdc73|CDC73]]|0.446|
|[[:human genes:c:cbwd6|CBWD6]]|0.446|
|[[:human genes:e:exosc6|EXOSC6]]|0.446|
|[[:human genes:n:nsf|NSF]]|0.446|
|[[:human genes:f:fbxw9|FBXW9]]|0.445|
|[[:human genes:l:lad1|LAD1]]|0.445|
|[[:human genes:d:ddt|DDT]]|0.444|
|[[:human genes:e:exosc3|EXOSC3]]|0.444|
|[[:human genes:r:riok2|RIOK2]]|0.443|
|[[:human genes:c:cbwd5|CBWD5]]|0.443|
|[[:human genes:n:nup160|NUP160]]|0.442|
|[[:human genes:c:cln6|CLN6]]|0.442|
|[[:human genes:s:sf3a1|SF3A1]]|0.441|
|[[:human genes:s:s1pr4|S1PR4]]|0.441|
|[[:human genes:t:tsg101|TSG101]]|0.441|
|[[:human genes:i:ik|IK]]|0.44|
|[[:human genes:t:ticrr|TICRR]]|0.44|
|[[:human genes:c:ccdc116|CCDC116]]|0.44|
|[[:human genes:h:hinfp|HINFP]]|0.44|
|[[:human genes:p:polr2j3|POLR2J3]]|0.439|
|[[:human genes:a:akirin2|AKIRIN2]]|0.439|
|[[:human genes:s:snrnp70|SNRNP70]]|0.439|
|[[:human genes:p:polr2a|POLR2A]]|0.438|
|[[:human genes:r:rbbp5|RBBP5]]|0.437|
|[[:human genes:r:rbm39|RBM39]]|0.437|
|[[:human genes:c:cdc45|CDC45]]|0.436|
|[[:human genes:r:rrp7a|RRP7A]]|0.434|
|[[:human genes:p:psmd14|PSMD14]]|0.434|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.433|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.432|
|[[:human genes:t:tspy8|TSPY8]]|0.431|
|[[:human genes:m:myo1h|MYO1H]]|0.431|
|[[:human genes:e:exosc9|EXOSC9]]|0.431|
|[[:human genes:m:mbtd1|MBTD1]]|0.431|
|[[:human genes:o:or10g3|OR10G3]]|0.43|
|[[:human genes:a:acd|ACD]]|0.43|
|[[:human genes:k:krt5|KRT5]]|0.43|
|[[:human genes:n:npipb5|NPIPB5]]|0.43|
|[[:human genes:p:psmd3|PSMD3]]|0.43|
|[[:human genes:p:psma7|PSMA7]]|0.43|
|[[:human genes:h:hivep3|HIVEP3]]|0.43|
|[[:human genes:n:nol12|NOL12]]|0.429|
|[[:human genes:s:snrpa1|SNRPA1]]|0.429|
|[[:human genes:v:vps28|VPS28]]|0.429|
|[[:human genes:n:nup85|NUP85]]|0.428|
|[[:human genes:o:orc6|ORC6]]|0.428|
|[[:human genes:p:psmc6|PSMC6]]|0.427|
|[[:human genes:d:ddx41|DDX41]]|0.427|
|[[:human genes:g:gid4|GID4]]|0.427|
|[[:human genes:m:madcam1|MADCAM1]]|0.425|
|[[:human genes:p:polr1a|POLR1A]]|0.424|
|[[:human genes:t:timeless|TIMELESS]]|0.424|
|[[:human genes:a:aamp|AAMP]]|0.424|
|[[:human genes:r:rrm1|RRM1]]|0.423|
|[[:human genes:v:vasn|VASN]]|0.423|
|[[:human genes:g:gprin2|GPRIN2]]|0.423|
|[[:human genes:e:exosc5|EXOSC5]]|0.422|
|[[:human genes:r:rpl30|RPL30]]|0.422|
|[[:human genes:s:smtn|SMTN]]|0.421|
|[[:human genes:b:brd2|BRD2]]|0.42|
|[[:human genes:p:pole|POLE]]|0.42|
|[[:human genes:n:nol8|NOL8]]|0.419|
|[[:human genes:d:dtl|DTL]]|0.419|
|[[:human genes:w:wdr87|WDR87]]|0.418|
|[[:human genes:t:terf1|TERF1]]|0.418|
|[[:human genes:p:psmd2|PSMD2]]|0.417|
|[[:human genes:s:sf3a2|SF3A2]]|0.417|
|[[:human genes:c:chmp2a|CHMP2A]]|0.417|
|[[:human genes:m:mki67ip|MKI67IP]]|0.416|
|[[:human genes:r:rpl17|RPL17]]|0.416|
|[[:human genes:c:copa|COPA]]|0.416|
|[[:human genes:p:polr2f|POLR2F]]|0.416|
|[[:human genes:b:bysl|BYSL]]|0.415|
|[[:human genes:i:igfn1|IGFN1]]|0.415|
|[[:human genes:d:dido1|DIDO1]]|0.414|
|[[:human genes:c:chchd3|CHCHD3]]|0.414|
|[[:human genes:d:dock6|DOCK6]]|0.414|
|[[:human genes:p:plk1|PLK1]]|0.414|
|[[:human genes:p:pcf11|PCF11]]|0.414|
|[[:human genes:c:cep192|CEP192]]|0.413|
|[[:human genes:l:loc643669|LOC643669]]|0.413|
|[[:human genes:c:chmp4b|CHMP4B]]|0.413|
|[[:human genes:c:cdh24|CDH24]]|0.413|
|[[:human genes:z:znf655|ZNF655]]|0.412|
|[[:human genes:n:npipa5|NPIPA5]]|0.412|
|[[:human genes:s:slc6a17|SLC6A17]]|0.412|
|[[:human genes:e:exd1|EXD1]]|0.411|
|[[:human genes:m:mepce|MEPCE]]|0.411|
|[[:human genes:p:polr2l|POLR2L]]|0.411|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.41|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.41|
|[[:human genes:p:pola2|POLA2]]|0.408|
|[[:human genes:p:prpf19|PRPF19]]|0.407|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.407|
|[[:human genes:z:znf148|ZNF148]]|0.406|
|[[:human genes:n:nol9|NOL9]]|0.406|
|[[:human genes:a:arcn1|ARCN1]]|0.405|
|[[:human genes:e:egr2|EGR2]]|0.405|
|[[:human genes:r:rps5|RPS5]]|0.404|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.404|
|[[:human genes:x:xab2|XAB2]]|0.404|
|[[:human genes:s:sult2b1|SULT2B1]]|0.404|
|[[:human genes:s:sap30bp|SAP30BP]]|0.403|
|[[:human genes:n:nop14|NOP14]]|0.403|
|[[:human genes:c:cgb2|CGB2]]|0.403|
|[[:human genes:r:rrn3|RRN3]]|0.402|
|[[:human genes:s:sf3a3|SF3A3]]|0.402|
|[[:human genes:s:sec13|SEC13]]|0.402|
|[[:human genes:f:fcn2|FCN2]]|0.402|
|[[:human genes:r:rpl37a|RPL37A]]|0.401|
|[[:human genes:n:ncl|NCL]]|0.401|
|[[:human genes:s:slc38a7|SLC38A7]]|0.401|
|[[:human genes:n:nfs1|NFS1]]|0.401|
|[[:human genes:r:rrp1|RRP1]]|0.4|
|[[:human genes:x:xylt2|XYLT2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 566/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|21/28|
|bone|18/26|
|breast|28/33|
|central nervous system|36/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|14/21|
|liver|16/20|
|lung|58/75|
|lymphocyte|14/16|
|ovary|20/26|
|pancreas|21/24|
|peripheral nervous system|12/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|15/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1929
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACTIN Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>