======= CALCR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CALCR
  * **<color #00a2e8>Official Name</color>**: calcitonin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=799|799]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30988|P30988]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CALCR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CALCR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114131|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcitonin binding|
|calcitonin receptor activity|
|positive regulation of calcium ion import across plasma membrane|
|cross-receptor inhibition within G protein-coupled receptor heterodimer|
|amylin receptor complex 2|
|amylin receptor complex 1|
|amylin receptor complex 3|
|amylin receptor activity|
|calcitonin gene-related peptide receptor activity|
|regulation of calcium ion import across plasma membrane|
|amylin receptor signaling pathway|
|calcitonin family receptor signaling pathway|
|positive regulation of protein kinase A signaling|
|regulation of protein kinase A signaling|
|positive regulation of calcium ion import|
|activation of adenylate cyclase activity|
|regulation of calcium ion import|
|response to amyloid-beta|
|positive regulation of calcium ion transport into cytosol|
|negative regulation of signaling receptor activity|
|positive regulation of calcium ion transmembrane transport|
|amyloid-beta binding|
|regulation of calcium ion transport into cytosol|
|positive regulation of peptidyl-serine phosphorylation|
|positive regulation of calcium ion transport|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of cation transmembrane transport|
|regulation of G protein-coupled receptor signaling pathway|
|response to glucocorticoid|
|cAMP-mediated signaling|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|response to corticosteroid|
|positive regulation of protein kinase B signaling|
|cyclic-nucleotide-mediated signaling|
|regulation of signaling receptor activity|
|positive regulation of transmembrane transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein kinase B signaling|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of ERK1 and ERK2 cascade|
|axon|
|response to steroid hormone|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|regulation of metal ion transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|positive regulation of MAPK cascade|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-2.25|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.92|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9781
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CALCR Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>