======= CALCRL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CALCRL
  * **<color #00a2e8>Official Name</color>**: calcitonin receptor like receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10203|10203]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16602|Q16602]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CALCRL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CALCRL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. {ECO:0000250, ECO:0000269|PubMed:22102369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HRM|
|7tm 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to disaccharide stimulus|
|cellular response to sucrose stimulus|
|calcitonin gene-related peptide receptor signaling pathway|
|adrenomedullin binding|
|CGRP receptor complex|
|calcitonin receptor activity|
|adrenomedullin receptor complex|
|adrenomedullin receptor activity|
|adrenomedullin receptor signaling pathway|
|calcitonin gene-related peptide receptor activity|
|response to disaccharide|
|response to sucrose|
|calcitonin family receptor signaling pathway|
|negative regulation of smooth muscle contraction|
|negative regulation of muscle contraction|
|regulation of smooth muscle contraction|
|receptor internalization|
|cellular response to carbohydrate stimulus|
|positive regulation of smooth muscle cell proliferation|
|receptor metabolic process|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of smooth muscle cell proliferation|
|negative regulation of inflammatory response|
|cAMP-mediated signaling|
|regulation of muscle contraction|
|cyclic-nucleotide-mediated signaling|
|response to carbohydrate|
|negative regulation of defense response|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of muscle system process|
|receptor-mediated endocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|lysosome|
|endosome|
|divalent metal ion transport|
|divalent inorganic cation transport|
|angiogenesis|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|negative regulation of response to external stimulus|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|endocytosis|
|regulation of system process|
|metal ion transport|
|tube morphogenesis|
|import into cell|
|G protein-coupled receptor activity|
|regulation of defense response|
|cation transport|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|endoplasmic reticulum|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|G protein-coupled receptor signaling pathway|
|ion transport|
|integral component of plasma membrane|
|regulation of response to stress|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CALCRL Expression in NALM6 Cells: 1.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>