======= CALM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CALM1
  * **<color #00a2e8>Official Name</color>**: calmodulin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=801|801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DP23|P0DP23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CALM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CALM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand Ca insen|
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation by host of symbiont cAMP-mediated signal transduction|
|modulation by host of symbiont cAMP-mediated signal transduction|
|N-terminal myristoylation domain binding|
|positive regulation by organism of signal transduction in other organism involved in symbiotic interaction|
|positive regulation of signal transduction in other organism|
|modulation by host of symbiont signal transduction pathway|
|positive regulation by host of symbiont signal transduction pathway|
|positive regulation of cyclic-nucleotide phosphodiesterase activity|
|modulation of signal transduction in other organism|
|adenylate cyclase activator activity|
|modulation of signal transduction in other organism involved in symbiotic interaction|
|catalytic complex|
|positive regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of cyclic-nucleotide phosphodiesterase activity|
|regulation of cell communication by electrical coupling involved in cardiac conduction|
|protein phosphatase activator activity|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of cell communication by electrical coupling|
|calcium channel inhibitor activity|
|detection of calcium ion|
|adenylate cyclase binding|
|titin binding|
|negative regulation of release of sequestered calcium ion into cytosol|
|positive regulation of sequestering of calcium ion|
|glycogen catabolic process|
|glucan catabolic process|
|negative regulation of peptidyl-threonine phosphorylation|
|negative regulation of calcium ion transport into cytosol|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|cellular polysaccharide catabolic process|
|positive regulation of phosphoprotein phosphatase activity|
|polysaccharide catabolic process|
|positive regulation of cAMP-mediated signaling|
|calcium channel complex|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of rhodopsin mediated signaling pathway|
|regulation of ryanodine-sensitive calcium-release channel activity|
|positive regulation of protein autophosphorylation|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|positive regulation of peptidyl-threonine phosphorylation|
|protein serine/threonine kinase activator activity|
|negative regulation of calcium-mediated signaling|
|disordered domain specific binding|
|positive regulation of phosphatase activity|
|negative regulation of calcium ion transmembrane transporter activity|
|Wnt signaling pathway, calcium modulating pathway|
|spindle microtubule|
|cellular carbohydrate catabolic process|
|negative regulation of calcium ion transmembrane transport|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of release of sequestered calcium ion into cytosol|
|negative regulation of cation channel activity|
|positive regulation of calcium-mediated signaling|
|substantia nigra development|
|positive regulation of protein dephosphorylation|
|regulation of nitric-oxide synthase activity|
|regulation of peptidyl-threonine phosphorylation|
|regulation of protein autophosphorylation|
|regulation of cAMP-mediated signaling|
|glycogen metabolic process|
|cellular glucan metabolic process|
|glucan metabolic process|
|sarcomere|
|positive regulation of calcium ion transport into cytosol|
|regulation of monooxygenase activity|
|inositol phosphate metabolic process|
|positive regulation of dephosphorylation|
|negative regulation of calcium ion transport|
|neural nucleus development|
|energy reserve metabolic process|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|modification by host of symbiont morphology or physiology|
|negative regulation of ion transmembrane transporter activity|
|regulation of cardiac muscle contraction|
|interaction with symbiont|
|regulation of release of sequestered calcium ion into cytosol|
|cellular polysaccharide metabolic process|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|polysaccharide metabolic process|
|midbrain development|
|regulation of calcium ion transmembrane transporter activity|
|regulation of cytokinesis|
|regulation of striated muscle contraction|
|negative regulation of ion transmembrane transport|
|regulation of oxidoreductase activity|
|regulation of heart rate|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|positive regulation of ion transmembrane transporter activity|
|polyol metabolic process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|regulation of phosphoprotein phosphatase activity|
|carbohydrate catabolic process|
|positive regulation of calcium ion transport|
|spindle pole|
|regulation of sequestering of calcium ion|
|ion channel binding|
|platelet degranulation|
|non-canonical Wnt signaling pathway|
|regulation of protein dephosphorylation|
|vesicle|
|positive regulation of cation transmembrane transport|
|regulation of G protein-coupled receptor signaling pathway|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|response to calcium ion|
|positive regulation of ion transmembrane transport|
|modification of morphology or physiology of other organism|
|regulation of muscle contraction|
|regulation of cell division|
|cellular carbohydrate metabolic process|
|regulation of cation channel activity|
|Fc-epsilon receptor signaling pathway|
|regulation of phosphatase activity|
|positive regulation of transmembrane transport|
|regulation of dephosphorylation|
|energy derivation by oxidation of organic compounds|
|regulation of muscle system process|
|Fc receptor signaling pathway|
|regulation of heart contraction|
|protein domain specific binding|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|muscle system process|
|alcohol metabolic process|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|response to metal ion|
|MAPK cascade|
|regulation of metal ion transport|
|signal transduction by protein phosphorylation|
|negative regulation of protein phosphorylation|
|generation of precursor metabolites and energy|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cellular calcium ion homeostasis|
|cofactor metabolic process|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|carbohydrate metabolic process|
|regulation of ion transmembrane transport|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|centrosome|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|detection of chemical stimulus|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|immune response-regulating signaling pathway|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|detection of stimulus|
|regulation of ion transport|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|brain development|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular homeostasis|
|regulation of cellular localization|
|oxidation-reduction process|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|regulation of cell cycle|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.01|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.95|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.86|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.77|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.71|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.71|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CALM1 Expression in NALM6 Cells: 7.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>