======= CALM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CALM2
  * **<color #00a2e8>Official Name</color>**: calmodulin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=805|805]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DP24|P0DP24]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CALM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CALM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114182|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand Ca insen|
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|modulation by host of symbiont cAMP-mediated signal transduction|
|positive regulation by host of symbiont cAMP-mediated signal transduction|
|positive regulation by host of symbiont signal transduction pathway|
|modulation by host of symbiont signal transduction pathway|
|positive regulation of signal transduction in other organism|
|positive regulation by organism of signal transduction in other organism involved in symbiotic interaction|
|N-terminal myristoylation domain binding|
|adenylate cyclase activator activity|
|modulation of signal transduction in other organism|
|positive regulation of cyclic-nucleotide phosphodiesterase activity|
|modulation of signal transduction in other organism involved in symbiotic interaction|
|catalytic complex|
|positive regulation of ryanodine-sensitive calcium-release channel activity|
|regulation of cell communication by electrical coupling involved in cardiac conduction|
|regulation of cyclic-nucleotide phosphodiesterase activity|
|protein phosphatase activator activity|
|regulation of cell communication by electrical coupling|
|negative regulation of ryanodine-sensitive calcium-release channel activity|
|calcium channel inhibitor activity|
|detection of calcium ion|
|adenylate cyclase binding|
|titin binding|
|negative regulation of release of sequestered calcium ion into cytosol|
|positive regulation of sequestering of calcium ion|
|negative regulation of calcium ion transport into cytosol|
|negative regulation of peptidyl-threonine phosphorylation|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|positive regulation of phosphoprotein phosphatase activity|
|positive regulation of cAMP-mediated signaling|
|calcium channel complex|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of ryanodine-sensitive calcium-release channel activity|
|positive regulation of protein autophosphorylation|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|protein serine/threonine kinase activator activity|
|positive regulation of peptidyl-threonine phosphorylation|
|negative regulation of calcium-mediated signaling|
|disordered domain specific binding|
|positive regulation of phosphatase activity|
|negative regulation of calcium ion transmembrane transporter activity|
|spindle microtubule|
|positive regulation of calcium ion transmembrane transporter activity|
|negative regulation of calcium ion transmembrane transport|
|positive regulation of release of sequestered calcium ion into cytosol|
|positive regulation of calcium-mediated signaling|
|negative regulation of cation channel activity|
|substantia nigra development|
|regulation of peptidyl-threonine phosphorylation|
|positive regulation of protein dephosphorylation|
|regulation of protein autophosphorylation|
|regulation of cAMP-mediated signaling|
|sarcomere|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of dephosphorylation|
|negative regulation of calcium ion transport|
|neural nucleus development|
|regulation of cardiac conduction|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|modification by host of symbiont morphology or physiology|
|regulation of cardiac muscle contraction|
|interaction with symbiont|
|regulation of release of sequestered calcium ion into cytosol|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|midbrain development|
|regulation of calcium ion transmembrane transporter activity|
|regulation of cytokinesis|
|regulation of striated muscle contraction|
|negative regulation of ion transmembrane transport|
|regulation of heart rate|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|positive regulation of ion transmembrane transporter activity|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|regulation of phosphoprotein phosphatase activity|
|positive regulation of calcium ion transport|
|spindle pole|
|regulation of sequestering of calcium ion|
|ion channel binding|
|regulation of protein dephosphorylation|
|positive regulation of cation transmembrane transport|
|vesicle|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|response to calcium ion|
|positive regulation of ion transmembrane transport|
|modification of morphology or physiology of other organism|
|regulation of muscle contraction|
|regulation of cell division|
|regulation of cation channel activity|
|regulation of phosphatase activity|
|positive regulation of transmembrane transport|
|regulation of dephosphorylation|
|regulation of muscle system process|
|regulation of heart contraction|
|protein domain specific binding|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|response to metal ion|
|regulation of metal ion transport|
|negative regulation of protein phosphorylation|
|cellular calcium ion homeostasis|
|negative regulation of phosphorylation|
|calcium ion homeostasis|
|protein kinase binding|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|centrosome|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|detection of chemical stimulus|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|protein-containing complex|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|detection of stimulus|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|brain development|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|head development|
|symbiotic process|
|ion homeostasis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cellular localization|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-3.39|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-3.16|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.54|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.43|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.43|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.38|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.22|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.1|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.07|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.93|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.9|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.86|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.86|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.82|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.27|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:aspm|ASPM]]|0.521|
|[[:human genes:t:tacc3|TACC3]]|0.457|
|[[:human genes:d:dlgap5|DLGAP5]]|0.427|
|[[:human genes:s:sephs1|SEPHS1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17097
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CALM2 Expression in NALM6 Cells: 8.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>