======= CAMK2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMK2A
  * **<color #00a2e8>Official Name</color>**: calcium/calmodulin dependent protein kinase II alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=815|815]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQM7|Q9UQM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMK2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMK2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114078|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:23805378}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|CaMKII AD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of synaptic vesicle docking|
|calcium- and calmodulin-dependent protein kinase complex|
|peptidyl-threonine autophosphorylation|
|regulation of vesicle docking|
|glutamate receptor binding|
|calcium-dependent protein serine/threonine kinase activity|
|angiotensin-activated signaling pathway|
|positive regulation of striated muscle cell apoptotic process|
|positive regulation of cardiac muscle cell apoptotic process|
|cellular response to angiotensin|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|calmodulin-dependent protein kinase activity|
|response to angiotensin|
|positive regulation of muscle cell apoptotic process|
|dendritic spine development|
|Wnt signaling pathway, calcium modulating pathway|
|regulation of cardiac muscle cell apoptotic process|
|regulation of striated muscle cell apoptotic process|
|regulation of neuron migration|
|response to ischemia|
|regulation of neuronal synaptic plasticity|
|dendrite morphogenesis|
|apoptotic mitochondrial changes|
|regulation of muscle cell apoptotic process|
|endocytic vesicle membrane|
|regulation of mitochondrial membrane permeability|
|interferon-gamma-mediated signaling pathway|
|regulation of synaptic vesicle exocytosis|
|regulation of cellular response to heat|
|kinase activity|
|regulation of membrane permeability|
|Schaffer collateral - CA1 synapse|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|dendrite development|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|positive regulation of calcium ion transport|
|mitochondrial membrane organization|
|non-canonical Wnt signaling pathway|
|regulation of neurotransmitter transport|
|dendritic spine|
|positive regulation of NF-kappaB transcription factor activity|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|peptidyl-serine phosphorylation|
|response to interferon-gamma|
|regulation of synaptic plasticity|
|protein autophosphorylation|
|peptidyl-serine modification|
|postsynaptic membrane|
|calmodulin binding|
|mitochondrial transport|
|regulation of exocytosis|
|regulation of calcium ion transport|
|calcium ion transport|
|postsynaptic density|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to peptide hormone stimulus|
|mitotic cell cycle phase transition|
|positive regulation of ion transport|
|cell cycle phase transition|
|divalent metal ion transport|
|divalent inorganic cation transport|
|neuron projection|
|cellular response to peptide|
|regulation of neurotransmitter levels|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|protein serine/threonine kinase activity|
|regulation of metal ion transport|
|response to peptide hormone|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|mitochondrion organization|
|regulation of trans-synaptic signaling|
|response to peptide|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|cell junction|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion transport|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|neuron projection development|
|cytokine-mediated signaling pathway|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of ion transport|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of secretion by cell|
|innate immune response|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|cation transport|
|regulation of cell migration|
|membrane organization|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|defense response to other organism|
|protein phosphorylation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|programmed cell death|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|mitochondrion|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|cell cycle|
|defense response|
|ion transport|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|neurogenesis|
|cell development|
|regulation of cell death|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11519
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMK2A Expression in NALM6 Cells: 0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>