======= CAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAP1
  * **<color #00a2e8>Official Name</color>**: cyclase associated actin cytoskeleton regulatory protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10487|10487]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01518|Q01518]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617801|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAP N|
|CAP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase binding|
|activation of adenylate cyclase activity|
|actin polymerization or depolymerization|
|cortical actin cytoskeleton|
|azurophil granule lumen|
|ameboidal-type cell migration|
|establishment or maintenance of cell polarity|
|receptor-mediated endocytosis|
|actin filament organization|
|actin binding|
|focal adhesion|
|supramolecular fiber organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|endocytosis|
|actin filament-based process|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|import into cell|
|regulated exocytosis|
|cell morphogenesis|
|leukocyte mediated immunity|
|exocytosis|
|cellular component morphogenesis|
|leukocyte activation|
|cell migration|
|secretion by cell|
|export from cell|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|cytoskeleton organization|
|secretion|
|locomotion|
|movement of cell or subcellular component|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 86/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|3/28|
|bone|0/26|
|breast|7/33|
|central nervous system|1/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|2/20|
|lung|10/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5779
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAP1 Expression in NALM6 Cells: 7.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>