======= CAPG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAPG
  * **<color #00a2e8>Official Name</color>**: capping actin protein, gelsolin like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=822|822]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40121|P40121]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAPG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAPG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153615|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gelsolin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|F-actin capping protein complex|
|positive regulation of podosome assembly|
|barbed-end actin filament capping|
|regulation of podosome assembly|
|Flemming body|
|actin filament capping|
|negative regulation of actin filament depolymerization|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|negative regulation of protein depolymerization|
|extracellular matrix disassembly|
|negative regulation of protein polymerization|
|negative regulation of protein complex disassembly|
|positive regulation of organelle assembly|
|mitotic spindle|
|regulation of protein depolymerization|
|ruffle|
|melanosome|
|regulation of protein complex disassembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|negative regulation of cytoskeleton organization|
|centriole|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|actin filament binding|
|regulation of organelle assembly|
|regulation of protein polymerization|
|protein domain specific binding|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|protein-containing complex binding|
|cadherin binding|
|extracellular matrix organization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|extracellular structure organization|
|regulation of actin filament-based process|
|cellular component disassembly|
|regulation of protein complex assembly|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of organelle organization|
|negative regulation of cellular component organization|
|nucleolus|
|regulation of cellular component biogenesis|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.92|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.75|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15666
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAPG Expression in NALM6 Cells: 0.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>