======= CAPN3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAPN3
  * **<color #00a2e8>Official Name</color>**: calpain 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=825|825]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20807|P20807]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAPN3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAPN3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114240|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-regulated non-lysosomal thiol-protease.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C2|
|efhand|
|Calpain III|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ligase regulator activity|
|calcium-dependent self proteolysis|
|positive regulation of satellite cell activation involved in skeletal muscle regeneration|
|regulation of satellite cell activation involved in skeletal muscle regeneration|
|G1 to G0 transition involved in cell differentiation|
|positive regulation of skeletal muscle tissue regeneration|
|self proteolysis|
|sodium ion binding|
|cellular response to salt stress|
|regulation of skeletal muscle tissue regeneration|
|G1 to G0 transition|
|negative regulation of protein sumoylation|
|titin binding|
|calcium-dependent cysteine-type endopeptidase activity|
|muscle cell cellular homeostasis|
|regulation of protein sumoylation|
|response to salt stress|
|response to muscle activity|
|myofibril|
|cysteine-type peptidase activity|
|cellular response to osmotic stress|
|positive regulation of release of sequestered calcium ion into cytosol|
|T-tubule|
|catalytic activity|
|structural constituent of muscle|
|protein destabilization|
|sarcomere organization|
|molecular adaptor activity|
|regulation of myoblast differentiation|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of wound healing|
|positive regulation of response to wounding|
|response to activity|
|myofibril assembly|
|positive regulation of calcium ion transmembrane transport|
|response to osmotic stress|
|regulation of release of sequestered calcium ion into cytosol|
|peptidase activity|
|negative regulation of protein modification by small protein conjugation or removal|
|cellular response to calcium ion|
|intracellular|
|regulation of calcium ion transport into cytosol|
|cellular component assembly involved in morphogenesis|
|actomyosin structure organization|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|Z disc|
|striated muscle cell development|
|regulation of wound healing|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|muscle cell development|
|response to calcium ion|
|positive regulation of NF-kappaB transcription factor activity|
|positive regulation of ion transmembrane transport|
|regulation of response to wounding|
|positive regulation of developmental growth|
|cellular response to metal ion|
|striated muscle cell differentiation|
|positive regulation of transmembrane transport|
|cellular response to inorganic substance|
|regulation of protein modification by small protein conjugation or removal|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|muscle cell differentiation|
|regulation of calcium ion transport|
|positive regulation of growth|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of protein stability|
|muscle organ development|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of cytosolic calcium ion concentration|
|regulation of developmental growth|
|regulation of cation transmembrane transport|
|anatomical structure homeostasis|
|positive regulation of proteolysis|
|response to metal ion|
|regulation of metal ion transport|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|response to inorganic substance|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|actin filament-based process|
|negative regulation of protein modification process|
|protein-containing complex|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|regulation of growth|
|protein catabolic process|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of proteolysis|
|cellular chemical homeostasis|
|organelle assembly|
|ion homeostasis|
|cellular component morphogenesis|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|negative regulation of RNA metabolic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.71|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.77|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.82|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5111
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAPN3 Expression in NALM6 Cells: 3.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>