======= CARD10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CARD10
  * **<color #00a2e8>Official Name</color>**: caspase recruitment domain family member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29775|29775]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BWT7|Q9BWT7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CARD10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CARD10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607209|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activates NF-kappa-B via BCL10 and IKK.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CBM complex|
|negative regulation of cell migration involved in sprouting angiogenesis|
|CARD domain binding|
|activation of NF-kappaB-inducing kinase activity|
|receptor signaling complex adaptor activity|
|negative regulation of sprouting angiogenesis|
|negative regulation of blood vessel endothelial cell migration|
|regulation of cell migration involved in sprouting angiogenesis|
|negative regulation of endothelial cell migration|
|negative regulation of epithelial cell migration|
|regulation of sprouting angiogenesis|
|positive regulation of protein localization to nucleus|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|regulation of blood vessel endothelial cell migration|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|regulation of NIK/NF-kappaB signaling|
|negative regulation of vasculature development|
|regulation of protein localization to nucleus|
|regulation of endothelial cell migration|
|regulation of epithelial cell migration|
|negative regulation of cell migration|
|negative regulation of cell motility|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|activation of protein kinase activity|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of protein kinase activity|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of cellular localization|
|negative regulation of developmental process|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.16|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.89|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.74|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.71|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.75|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.78|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CARD10 Expression in NALM6 Cells: -1.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>