======= CARD11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CARD11
  * **<color #00a2e8>Official Name</color>**: caspase recruitment domain family member 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84433|84433]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXL7|Q9BXL7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CARD11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CARD11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway. {ECO:0000269|PubMed:11278692, ECO:0000269|PubMed:11356195, ECO:0000269|PubMed:12356734, ECO:0000269|PubMed:28628108}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-2 secretion|
|CBM complex|
|TORC1 signaling|
|interleukin-2 production|
|guanylate kinase activity|
|GDP metabolic process|
|positive regulation of interleukin-2 biosynthetic process|
|GMP metabolic process|
|CARD domain binding|
|regulation of interleukin-2 biosynthetic process|
|thymic T cell selection|
|regulation of B cell differentiation|
|TOR signaling|
|positive regulation of interleukin-2 production|
|immunological synapse|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|T cell selection|
|B cell proliferation|
|guanosine-containing compound metabolic process|
|positive regulation of B cell proliferation|
|T cell differentiation in thymus|
|cytokine secretion|
|ribonucleoside monophosphate metabolic process|
|T cell costimulation|
|regulation of interleukin-2 production|
|lymphocyte costimulation|
|regulation of B cell proliferation|
|purine ribonucleoside metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|purine nucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|purine nucleoside metabolic process|
|positive regulation of cytokine biosynthetic process|
|I-kappaB kinase/NF-kappaB signaling|
|nucleoside monophosphate metabolic process|
|ribonucleoside metabolic process|
|nucleoside diphosphate metabolic process|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|positive regulation of T cell proliferation|
|leukocyte proliferation|
|regulation of cytokine biosynthetic process|
|B cell differentiation|
|nucleoside metabolic process|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|glycosyl compound metabolic process|
|T cell differentiation|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|B cell activation|
|immunoglobulin production|
|regulation of T cell proliferation|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|positive regulation of B cell activation|
|regulation of lymphocyte differentiation|
|peptide secretion|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|production of molecular mediator of immune response|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|membrane raft|
|innate immune response-activating signal transduction|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|T cell activation|
|lymphocyte differentiation|
|Fc receptor signaling pathway|
|positive regulation of cell-cell adhesion|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|regulation of leukocyte differentiation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|purine ribonucleotide metabolic process|
|regulation of T cell activation|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|leukocyte differentiation|
|ribose phosphate metabolic process|
|positive regulation of innate immune response|
|positive regulation of lymphocyte activation|
|positive regulation of response to biotic stimulus|
|purine-containing compound metabolic process|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|nucleotide metabolic process|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|nucleoside phosphate metabolic process|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|nucleobase-containing small molecule metabolic process|
|cell population proliferation|
|hemopoiesis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|organophosphate metabolic process|
|positive regulation of cell population proliferation|
|leukocyte activation|
|secretion by cell|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|export from cell|
|cell activation|
|regulation of response to external stimulus|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of response to stress|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.25|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.89|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.86|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.82|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.72|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.7|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.78|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.01|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.15|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CARD11 Expression in NALM6 Cells: -0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>