======= CARD16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CARD16
  * **<color #00a2e8>Official Name</color>**: caspase recruitment domain family member 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114769|114769]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5EG05|Q5EG05]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CARD16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CARD16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615680|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. {ECO:0000269|PubMed:11432859, ECO:0000269|PubMed:11536016, ECO:0000269|PubMed:16920334}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protease inhibitor complex|
|cellular response to UV-C|
|caspase binding|
|inhibition of cysteine-type endopeptidase activity|
|zymogen inhibition|
|negative regulation of lipopolysaccharide-mediated signaling pathway|
|negative regulation of interleukin-1 beta secretion|
|CARD domain binding|
|response to UV-C|
|negative regulation of interleukin-1 secretion|
|negative regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of lipopolysaccharide-mediated signaling pathway|
|negative regulation of interleukin-1 beta production|
|negative regulation of protein maturation|
|cysteine-type endopeptidase inhibitor activity|
|negative regulation of interleukin-1 production|
|negative regulation of protein processing|
|regulation of interleukin-1 beta secretion|
|regulation of interleukin-1 secretion|
|regulation of tumor necrosis factor-mediated signaling pathway|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|regulation of protein processing|
|regulation of protein maturation|
|negative regulation of cytokine secretion|
|regulation of interleukin-1 beta production|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to UV|
|negative regulation of cysteine-type endopeptidase activity|
|kinase binding|
|negative regulation of response to biotic stimulus|
|regulation of interleukin-1 production|
|negative regulation of protein binding|
|cellular response to light stimulus|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|response to UV|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of binding|
|cellular response to radiation|
|regulation of response to cytokine stimulus|
|negative regulation of protein transport|
|cellular response to lipopolysaccharide|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of establishment of protein localization|
|cellular response to hypoxia|
|cellular response to molecule of bacterial origin|
|cellular response to decreased oxygen levels|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|cellular response to biotic stimulus|
|negative regulation of multi-organism process|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of protein binding|
|negative regulation of secretion|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of cytokine production|
|response to light stimulus|
|response to lipopolysaccharide|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|response to molecule of bacterial origin|
|response to hypoxia|
|negative regulation of proteolysis|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|regulation of binding|
|response to oxygen levels|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|protein-containing complex|
|response to bacterium|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of secretion|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|identical protein binding|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.79|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.73|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13482
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CARD16 Expression in NALM6 Cells: -0.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>