======= CASC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CASC3
  * **<color #00a2e8>Official Name</color>**: CASC3 exon junction complex subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22794|22794]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15234|O15234]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CASC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CASC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606504|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Btz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular mRNA localization|
|U2-type catalytic step 1 spliceosome|
|exon-exon junction complex|
|cytoplasmic stress granule|
|mRNA 3-end processing|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|RNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|ubiquitin protein ligase binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|enzyme binding|
|regulation of translation|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|nuclear speck|
|regulation of cellular amide metabolic process|
|dendrite|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|identical protein binding|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.71|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|1.74|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.74|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.86|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd11|PSMD11]]|0.46|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.455|
|[[:human genes:d:ddtl|DDTL]]|0.442|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.429|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.424|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.424|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.423|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.423|
|[[:human genes:a:akirin2|AKIRIN2]]|0.423|
|[[:human genes:r:rps12|RPS12]]|0.422|
|[[:human genes:s:sf3a1|SF3A1]]|0.42|
|[[:human genes:i:iscu|ISCU]]|0.418|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.417|
|[[:human genes:t:tceb3c|TCEB3C]]|0.416|
|[[:human genes:b:bysl|BYSL]]|0.416|
|[[:human genes:p:plk4|PLK4]]|0.415|
|[[:human genes:c:c10orf55|C10orf55]]|0.415|
|[[:human genes:o:orc1|ORC1]]|0.414|
|[[:human genes:c:c14orf93|C14orf93]]|0.412|
|[[:human genes:s:sel1l|SEL1L]]|0.412|
|[[:human genes:r:rps2|RPS2]]|0.412|
|[[:human genes:n:npipb5|NPIPB5]]|0.41|
|[[:human genes:s:slc6a17|SLC6A17]]|0.407|
|[[:human genes:p:psmb1|PSMB1]]|0.406|
|[[:human genes:t:terf2|TERF2]]|0.402|
|[[:human genes:p:pola2|POLA2]]|0.401|
|[[:human genes:c:copb2|COPB2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1618
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CASC3 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>