======= CASP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CASP2
  * **<color #00a2e8>Official Name</color>**: caspase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=835|835]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42575|P42575]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CASP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CASP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600639|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C14|
|CARD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine-type endopeptidase activity involved in execution phase of apoptosis|
|ectopic germ cell programmed cell death|
|luteolysis|
|programmed cell death involved in cell development|
|cysteine-type endopeptidase activity involved in apoptotic process|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|ovulation cycle process|
|execution phase of apoptosis|
|positive regulation of neuron apoptotic process|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|neural retina development|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|ovulation cycle|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in cell cycle checkpoint|
|cellular response to mechanical stimulus|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|female gonad development|
|cysteine-type endopeptidase activity|
|positive regulation of neuron death|
|development of primary female sexual characteristics|
|mitotic DNA damage checkpoint|
|extrinsic apoptotic signaling pathway|
|negative regulation of G1/S transition of mitotic cell cycle|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|female sex differentiation|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|retina development in camera-type eye|
|DNA integrity checkpoint|
|intrinsic apoptotic signaling pathway|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|protein processing|
|regulation of cell cycle G1/S phase transition|
|positive regulation of apoptotic signaling pathway|
|cell cycle checkpoint|
|regulation of neuron apoptotic process|
|gonad development|
|negative regulation of mitotic cell cycle phase transition|
|response to mechanical stimulus|
|development of primary sexual characteristics|
|protein maturation|
|negative regulation of cell cycle phase transition|
|protein domain specific binding|
|sex differentiation|
|rhythmic process|
|aging|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|regulation of neuron death|
|camera-type eye development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|negative regulation of cell cycle process|
|cellular response to external stimulus|
|enzyme binding|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of cell cycle|
|regulation of apoptotic signaling pathway|
|regulation of mitotic cell cycle phase transition|
|reproductive structure development|
|reproductive system development|
|regulation of cell cycle phase transition|
|sensory organ development|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|mitotic cell cycle|
|positive regulation of cell death|
|brain development|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|head development|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|central nervous system development|
|negative regulation of cell death|
|cell cycle process|
|programmed cell death|
|identical protein binding|
|cell death|
|response to abiotic stimulus|
|regulation of cell cycle|
|mitochondrion|
|proteolysis|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.92|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.97|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.98|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.02|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|3.33|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|6.27|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|6.29|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|6.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.757|
|[[:human genes:c:c2cd3|C2CD3]]|0.723|
|[[:human genes:p:pibf1|PIBF1]]|0.71|
|[[:human genes:c:ccdc41|CCDC41]]|0.699|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.695|
|[[:human genes:o:ofd1|OFD1]]|0.693|
|[[:human genes:o:odf2|ODF2]]|0.66|
|[[:human genes:p:pidd|PIDD]]|0.655|
|[[:human genes:a:ankrd26|ANKRD26]]|0.652|
|[[:human genes:f:fopnl|FOPNL]]|0.636|
|[[:human genes:c:cep76|CEP76]]|0.618|
|[[:human genes:t:tubd1|TUBD1]]|0.613|
|[[:human genes:n:nin|NIN]]|0.598|
|[[:human genes:c:cep120|CEP120]]|0.598|
|[[:human genes:c:c14orf80|C14orf80]]|0.598|
|[[:human genes:s:sclt1|SCLT1]]|0.595|
|[[:human genes:c:c16orf59|C16orf59]]|0.595|
|[[:human genes:c:cep128|CEP128]]|0.588|
|[[:human genes:c:cep78|CEP78]]|0.581|
|[[:human genes:c:cep44|CEP44]]|0.521|
|[[:human genes:t:tube1|TUBE1]]|0.494|
|[[:human genes:h:hyls1|HYLS1]]|0.481|
|[[:human genes:i:ipp|IPP]]|0.471|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.433|
|[[:human genes:w:wbp11|WBP11]]|0.415|
|[[:human genes:r:rttn|RTTN]]|0.411|
|[[:human genes:c:cntrl|CNTRL]]|0.408|
|[[:human genes:k:kiaa0586|KIAA0586]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CASP2 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>