======= CAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAT
  * **<color #00a2e8>Official Name</color>**: catalase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=847|847]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04040|P04040]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/115500|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells. {ECO:0000269|PubMed:7882369}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Catalase|
|Catalase-rel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to ozone|
|catalase activity|
|response to L-ascorbic acid|
|response to phenylpropanoid|
|oxidoreductase activity, acting on peroxide as acceptor|
|aminoacylase activity|
|hemoglobin metabolic process|
|response to vitamin E|
|response to light intensity|
|UV protection|
|response to inactivity|
|antioxidant activity|
|response to vitamin A|
|response to hyperoxia|
|response to lead ion|
|hydrogen peroxide catabolic process|
|response to increased oxygen levels|
|NADP binding|
|hydrogen peroxide metabolic process|
|peroxisomal matrix|
|antibiotic catabolic process|
|peroxisomal membrane|
|cofactor catabolic process|
|response to cadmium ion|
|response to activity|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|triglyceride metabolic process|
|mitochondrial intermembrane space|
|peroxisome organization|
|aerobic respiration|
|negative regulation of NF-kappaB transcription factor activity|
|response to fatty acid|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|ureteric bud development|
|response to vitamin|
|mesonephric epithelium development|
|mesonephric tubule development|
|positive regulation of cell division|
|cellular oxidant detoxification|
|mesonephros development|
|protein homotetramerization|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|cellular detoxification|
|antibiotic metabolic process|
|peroxisome|
|reactive oxygen species metabolic process|
|secretory granule lumen|
|cholesterol metabolic process|
|response to hydrogen peroxide|
|regulation of phosphatidylinositol 3-kinase signaling|
|ficolin-1-rich granule lumen|
|osteoblast differentiation|
|response to ethanol|
|detoxification|
|secondary alcohol metabolic process|
|kidney epithelium development|
|sterol metabolic process|
|response to estradiol|
|heme binding|
|response to UV|
|drug catabolic process|
|response to monosaccharide|
|protein tetramerization|
|positive regulation of NF-kappaB transcription factor activity|
|negative regulation of DNA-binding transcription factor activity|
|cellular respiration|
|regulation of cell division|
|response to carbohydrate|
|response to reactive oxygen species|
|cellular response to toxic substance|
|response to nutrient|
|response to insulin|
|response to alcohol|
|energy derivation by oxidation of organic compounds|
|cellular response to oxidative stress|
|lysosome|
|steroid metabolic process|
|positive regulation of DNA-binding transcription factor activity|
|ossification|
|kidney development|
|aging|
|renal system development|
|response to antibiotic|
|response to light stimulus|
|alcohol metabolic process|
|urogenital system development|
|signaling receptor binding|
|protein homooligomerization|
|response to hypoxia|
|response to acid chemical|
|enzyme binding|
|response to decreased oxygen levels|
|protein targeting|
|response to metal ion|
|glycerolipid metabolic process|
|response to oxygen levels|
|response to oxidative stress|
|response to peptide hormone|
|focal adhesion|
|generation of precursor metabolites and energy|
|regulation of DNA-binding transcription factor activity|
|establishment of protein localization to organelle|
|cofactor metabolic process|
|response to radiation|
|organic hydroxy compound metabolic process|
|response to peptide|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|response to nutrient levels|
|neutrophil mediated immunity|
|drug metabolic process|
|cellular response to growth factor stimulus|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|response to growth factor|
|response to extracellular stimulus|
|response to inorganic substance|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|protein localization to organelle|
|leukocyte mediated immunity|
|exocytosis|
|tube development|
|response to lipid|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|leukocyte activation|
|cellular lipid metabolic process|
|oxidation-reduction process|
|Golgi apparatus|
|negative regulation of cell death|
|intracellular protein transport|
|response to organonitrogen compound|
|secretion by cell|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|response to drug|
|export from cell|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|epithelium development|
|secretion|
|negative regulation of molecular function|
|response to abiotic stimulus|
|lipid metabolic process|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.36|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13773
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAT Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>