======= CATSPER2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CATSPER2
  * **<color #00a2e8>Official Name</color>**: cation channel sperm associated 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=117155|117155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96P56|Q96P56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CATSPER2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CATSPER2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607249|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of cation channel proteins that localize to the flagellum of spermatozoa. Defects at this locus causes male infertility. Alternatively spliced transcript variants have been observed at this locus. Readthrough transcription originates upstream of this locus in diphosphoinositol pentakisphosphate kinase 1 pseudogene 1 and is represented by GeneID:110006325. Related pseudogenes are found next to this locus on chromosome 15 and on chromosome 5. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CatSper complex|
|calcium activated cation channel activity|
|sperm capacitation|
|voltage-gated ion channel activity|
|response to progesterone|
|sperm-egg recognition|
|calcium channel activity|
|cell-cell recognition|
|sperm motility|
|flagellated sperm motility|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|motile cilium|
|single fertilization|
|spermatid development|
|spermatid differentiation|
|cell maturation|
|fertilization|
|response to ketone|
|calcium ion transmembrane transport|
|cell recognition|
|developmental maturation|
|calcium ion transport|
|germ cell development|
|divalent metal ion transport|
|divalent inorganic cation transport|
|response to steroid hormone|
|cellular process involved in reproduction in multicellular organism|
|regulation of ion transmembrane transport|
|spermatogenesis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|male gamete generation|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|developmental process involved in reproduction|
|gamete generation|
|regulation of ion transport|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|multi-organism reproductive process|
|response to drug|
|cell motility|
|localization of cell|
|transmembrane transport|
|locomotion|
|ion transport|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|cell development|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.84|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.73|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.93|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6528
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CATSPER2 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>