======= CAV2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAV2
  * **<color #00a2e8>Official Name</color>**: caveolin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=858|858]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51636|P51636]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAV2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAV2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250, ECO:0000269|PubMed:15504032, ECO:0000269|PubMed:18081315}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Caveolin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endocytosis involved in viral entry into host cell|
|receptor-mediated endocytosis of virus by host cell|
|positive regulation by host of viral release from host cell|
|caveola assembly|
|positive regulation of dopamine receptor signaling pathway|
|modulation by host of viral release from host cell|
|plasma membrane raft assembly|
|plasma membrane raft organization|
|positive regulation of cellular response to drug|
|membrane raft assembly|
|regulation of dopamine receptor signaling pathway|
|positive regulation of viral release from host cell|
|positive regulation by host of viral process|
|acrosomal membrane|
|membrane raft organization|
|skeletal muscle fiber development|
|myotube cell development|
|modulation by host of viral process|
|regulation of viral release from host cell|
|positive regulation of response to drug|
|membrane assembly|
|regulation of cellular response to drug|
|negative regulation of endothelial cell proliferation|
|membrane biogenesis|
|endoplasmic reticulum organization|
|transport of virus|
|myotube differentiation|
|muscle fiber development|
|scaffold protein binding|
|positive regulation of viral life cycle|
|extrinsic component of cytoplasmic side of plasma membrane|
|vesicle docking|
|multi-organism localization|
|multi-organism transport|
|modification by host of symbiont morphology or physiology|
|vesicle fusion|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|caveola|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|interaction with symbiont|
|organelle membrane fusion|
|protein binding, bridging|
|insulin receptor signaling pathway|
|transport vesicle|
|plasma membrane organization|
|positive regulation of endothelial cell proliferation|
|viral entry into host cell|
|organelle fusion|
|regulation of response to drug|
|sarcolemma|
|entry into host cell|
|entry into host|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal muscle tissue development|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|membrane fusion|
|skeletal muscle organ development|
|striated muscle cell development|
|regulation of viral life cycle|
|negative regulation of cellular response to growth factor stimulus|
|muscle cell development|
|modification of morphology or physiology of other organism|
|interaction with host|
|cellular response to insulin stimulus|
|regulation of mitotic nuclear division|
|organelle localization by membrane tethering|
|membrane docking|
|positive regulation of epithelial cell proliferation|
|structural molecule activity|
|regulation of nuclear division|
|striated muscle cell differentiation|
|viral life cycle|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|membrane raft|
|response to insulin|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|receptor-mediated endocytosis|
|muscle cell differentiation|
|cytoplasmic vesicle|
|cellular response to peptide hormone stimulus|
|regulation of cellular response to growth factor stimulus|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|vesicle organization|
|cellular response to peptide|
|regulation of epithelial cell proliferation|
|response to peptide hormone|
|positive regulation of GTPase activity|
|focal adhesion|
|endomembrane system organization|
|mitochondrion organization|
|protein kinase binding|
|response to peptide|
|muscle structure development|
|regulation of GTPase activity|
|protein heterodimerization activity|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein complex oligomerization|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|endocytosis|
|organelle localization|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|Golgi membrane|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|import into cell|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|protein homodimerization activity|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|Golgi apparatus|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.7|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10559
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAV2 Expression in NALM6 Cells: 2.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>