======= CBFA2T3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CBFA2T3
  * **<color #00a2e8>Official Name</color>**: CBFA2/RUNX1 partner transcriptional co-repressor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=863|863]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75081|O75081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CBFA2T3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CBFA2T3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603870|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NHR2|
|TAFH|
|zf-MYND|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of aerobic respiration|
|negative regulation of glycolytic process|
|negative regulation of purine nucleotide metabolic process|
|negative regulation of nucleotide metabolic process|
|granulocyte differentiation|
|negative regulation of ATP metabolic process|
|regulation of cellular respiration|
|negative regulation of cellular carbohydrate metabolic process|
|negative regulation of carbohydrate metabolic process|
|regulation of glycolytic process|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|myeloid leukocyte differentiation|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of generation of precursor metabolites and energy|
|regulation of proteasomal protein catabolic process|
|regulation of carbohydrate metabolic process|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|myeloid cell differentiation|
|transcription corepressor activity|
|regulation of cellular protein catabolic process|
|negative regulation of catabolic process|
|leukocyte differentiation|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|response to oxygen levels|
|regulation of protein catabolic process|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|hematopoietic or lymphoid organ development|
|Golgi membrane|
|immune system development|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|nucleolus|
|regulation of catabolic process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.09|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.97|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.85|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.74|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.73|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.96|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.97|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2730
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CBFA2T3 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>