======= CBFB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CBFB
  * **<color #00a2e8>Official Name</color>**: core-binding factor subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=865|865]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13951|Q13951]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CBFB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CBFB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/121360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CBF beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core-binding factor complex|
|positive regulation of CD8-positive, alpha-beta T cell differentiation|
|positive regulation of CD8-positive, alpha-beta T cell activation|
|regulation of CD8-positive, alpha-beta T cell differentiation|
|regulation of CD8-positive, alpha-beta T cell activation|
|definitive hemopoiesis|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of bicellular tight junction assembly|
|negative regulation of alpha-beta T cell differentiation|
|regulation of B cell receptor signaling pathway|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of regulatory T cell differentiation|
|negative regulation of alpha-beta T cell activation|
|regulation of intracellular estrogen receptor signaling pathway|
|regulation of keratinocyte differentiation|
|negative regulation of T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of lymphocyte differentiation|
|regulation of megakaryocyte differentiation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of epidermal cell differentiation|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of alpha-beta T cell differentiation|
|regulation of hematopoietic stem cell differentiation|
|regulation of intracellular steroid hormone receptor signaling pathway|
|transcription coregulator activity|
|positive regulation of T cell differentiation|
|regulation of epidermis development|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of cell junction assembly|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|negative regulation of leukocyte differentiation|
|negative regulation of T cell activation|
|regulation of stem cell differentiation|
|negative regulation of leukocyte cell-cell adhesion|
|osteoblast differentiation|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of epithelial cell differentiation|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|cell maturation|
|regulation of cytokine-mediated signaling pathway|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|transcription initiation from RNA polymerase II promoter|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|DNA-templated transcription, initiation|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|lymphocyte differentiation|
|developmental maturation|
|positive regulation of cell-cell adhesion|
|ossification|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|transcription coactivator activity|
|regulation of leukocyte cell-cell adhesion|
|protein polyubiquitination|
|regulation of T cell activation|
|leukocyte differentiation|
|positive regulation of lymphocyte activation|
|regulation of Wnt signaling pathway|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|sequence-specific DNA binding|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|regulation of lymphocyte activation|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|protein ubiquitination|
|negative regulation of cell differentiation|
|protein modification by small protein conjugation|
|negative regulation of transcription by RNA polymerase II|
|leukocyte activation|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|regulation of immune response|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.36|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.34|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-2.32|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.31|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.16|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.14|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.12|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-2.09|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.02|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.99|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.95|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.92|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.9|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.89|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.83|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.82|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.77|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.73|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.72|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.7|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.7|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.7|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.76|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.79|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.85|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.93|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.95|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.99|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.14|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.18|
|[[:results:exp539|42°C R08 exp539]]|2.25|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.36|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.36|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.75|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|3.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.643|
|[[:human genes:r:runx1|RUNX1]]|0.639|
|[[:human genes:b:bap1|BAP1]]|0.628|
|[[:human genes:n:nsd1|NSD1]]|0.617|
|[[:human genes:d:dohh|DOHH]]|0.609|
|[[:human genes:i:id3|ID3]]|0.598|
|[[:human genes:d:dpagt1|DPAGT1]]|0.57|
|[[:human genes:x:xpo6|XPO6]]|0.568|
|[[:human genes:s:ssbp2|SSBP2]]|0.568|
|[[:human genes:r:rnmt|RNMT]]|0.564|
|[[:human genes:t:thg1l|THG1L]]|0.558|
|[[:human genes:m:med23|MED23]]|0.556|
|[[:human genes:t:triap1|TRIAP1]]|0.555|
|[[:human genes:p:pmm2|PMM2]]|0.552|
|[[:human genes:w:wdr24|WDR24]]|0.552|
|[[:human genes:g:gfpt1|GFPT1]]|0.548|
|[[:human genes:a:alg5|ALG5]]|0.547|
|[[:human genes:u:uhrf1|UHRF1]]|0.545|
|[[:human genes:g:gnb1l|GNB1L]]|0.535|
|[[:human genes:m:med16|MED16]]|0.533|
|[[:human genes:z:zfx|ZFX]]|0.53|
|[[:human genes:u:ube2g2|UBE2G2]]|0.529|
|[[:human genes:u:uap1|UAP1]]|0.529|
|[[:human genes:c:ccdc101|CCDC101]]|0.527|
|[[:human genes:g:gmppb|GMPPB]]|0.526|
|[[:human genes:m:mtor|MTOR]]|0.525|
|[[:human genes:t:tmem41b|TMEM41B]]|0.525|
|[[:human genes:l:lmo2|LMO2]]|0.524|
|[[:human genes:t:trmt10a|TRMT10A]]|0.521|
|[[:human genes:t:tti2|TTI2]]|0.517|
|[[:human genes:l:lsm11|LSM11]]|0.511|
|[[:human genes:a:alg1|ALG1]]|0.51|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.509|
|[[:human genes:a:aars|AARS]]|0.504|
|[[:human genes:v:vmp1|VMP1]]|0.504|
|[[:human genes:s:srp14|SRP14]]|0.5|
|[[:human genes:t:tti1|TTI1]]|0.5|
|[[:human genes:n:nae1|NAE1]]|0.498|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.498|
|[[:human genes:m:maml1|MAML1]]|0.498|
|[[:human genes:c:csnk2b|CSNK2B]]|0.495|
|[[:human genes:t:taz|TAZ]]|0.493|
|[[:human genes:p:ppa2|PPA2]]|0.489|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.486|
|[[:human genes:l:ldb1|LDB1]]|0.486|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.485|
|[[:human genes:r:rtcb|RTCB]]|0.485|
|[[:human genes:a:alg13|ALG13]]|0.484|
|[[:human genes:o:opa1|OPA1]]|0.484|
|[[:human genes:u:ube3a|UBE3A]]|0.483|
|[[:human genes:s:sox7|SOX7]]|0.481|
|[[:human genes:d:dnajc3|DNAJC3]]|0.48|
|[[:human genes:m:mapk14|MAPK14]]|0.478|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.477|
|[[:human genes:t:telo2|TELO2]]|0.475|
|[[:human genes:m:mbtps2|MBTPS2]]|0.475|
|[[:human genes:e:exoc4|EXOC4]]|0.474|
|[[:human genes:s:sec63|SEC63]]|0.473|
|[[:human genes:p:pelo|PELO]]|0.472|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.471|
|[[:human genes:o:otud5|OTUD5]]|0.471|
|[[:human genes:m:mllt1|MLLT1]]|0.47|
|[[:human genes:t:tle4|TLE4]]|0.47|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.467|
|[[:human genes:t:trim33|TRIM33]]|0.467|
|[[:human genes:h:hccs|HCCS]]|0.466|
|[[:human genes:a:alg6|ALG6]]|0.465|
|[[:human genes:s:slc25a26|SLC25A26]]|0.465|
|[[:human genes:c:cbx3|CBX3]]|0.463|
|[[:human genes:v:vhl|VHL]]|0.462|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.46|
|[[:human genes:t:trnt1|TRNT1]]|0.46|
|[[:human genes:c:chchd4|CHCHD4]]|0.459|
|[[:human genes:a:atp5j|ATP5J]]|0.459|
|[[:human genes:c:crls1|CRLS1]]|0.458|
|[[:human genes:p:pam16|PAM16]]|0.458|
|[[:human genes:a:alg2|ALG2]]|0.456|
|[[:human genes:r:rpn1|RPN1]]|0.453|
|[[:human genes:e:eny2|ENY2]]|0.452|
|[[:human genes:b:brd9|BRD9]]|0.451|
|[[:human genes:p:pik3r4|PIK3R4]]|0.451|
|[[:human genes:f:fli1|FLI1]]|0.451|
|[[:human genes:s:sec62|SEC62]]|0.451|
|[[:human genes:d:dad1|DAD1]]|0.45|
|[[:human genes:a:atp5b|ATP5B]]|0.449|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.449|
|[[:human genes:a:apaf1|APAF1]]|0.448|
|[[:human genes:s:ssb|SSB]]|0.447|
|[[:human genes:d:dhps|DHPS]]|0.446|
|[[:human genes:c:casp9|CASP9]]|0.445|
|[[:human genes:r:romo1|ROMO1]]|0.445|
|[[:human genes:a:atp5a1|ATP5A1]]|0.445|
|[[:human genes:s:slc35b1|SLC35B1]]|0.444|
|[[:human genes:f:fnta|FNTA]]|0.444|
|[[:human genes:m:mlst8|MLST8]]|0.444|
|[[:human genes:p:ppcs|PPCS]]|0.444|
|[[:human genes:c:cct7|CCT7]]|0.442|
|[[:human genes:e:eif4e|EIF4E]]|0.442|
|[[:human genes:o:osgep|OSGEP]]|0.441|
|[[:human genes:e:eif1|EIF1]]|0.44|
|[[:human genes:a:atp5o|ATP5O]]|0.439|
|[[:human genes:a:atp2a2|ATP2A2]]|0.438|
|[[:human genes:p:plaa|PLAA]]|0.438|
|[[:human genes:h:hspd1|HSPD1]]|0.437|
|[[:human genes:z:zbtb44|ZBTB44]]|0.437|
|[[:human genes:d:derl2|DERL2]]|0.436|
|[[:human genes:l:lsmd1|LSMD1]]|0.436|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.435|
|[[:human genes:d:dpm3|DPM3]]|0.435|
|[[:human genes:z:znf592|ZNF592]]|0.435|
|[[:human genes:a:atf7ip|ATF7IP]]|0.435|
|[[:human genes:h:haus8|HAUS8]]|0.431|
|[[:human genes:v:vezt|VEZT]]|0.43|
|[[:human genes:a:atp5d|ATP5D]]|0.43|
|[[:human genes:d:dpf2|DPF2]]|0.43|
|[[:human genes:d:dhx29|DHX29]]|0.429|
|[[:human genes:z:zmym2|ZMYM2]]|0.428|
|[[:human genes:k:kdsr|KDSR]]|0.427|
|[[:human genes:w:wdr59|WDR59]]|0.426|
|[[:human genes:z:znf410|ZNF410]]|0.426|
|[[:human genes:t:trim28|TRIM28]]|0.426|
|[[:human genes:r:rpp21|RPP21]]|0.424|
|[[:human genes:b:bak1|BAK1]]|0.423|
|[[:human genes:s:sdha|SDHA]]|0.423|
|[[:human genes:s:srp72|SRP72]]|0.423|
|[[:human genes:a:arih1|ARIH1]]|0.423|
|[[:human genes:v:vrk1|VRK1]]|0.423|
|[[:human genes:a:atxn10|ATXN10]]|0.423|
|[[:human genes:d:dhdds|DHDDS]]|0.422|
|[[:human genes:s:scaf8|SCAF8]]|0.422|
|[[:human genes:p:patz1|PATZ1]]|0.42|
|[[:human genes:s:stt3a|STT3A]]|0.418|
|[[:human genes:t:timm13|TIMM13]]|0.418|
|[[:human genes:r:rft1|RFT1]]|0.417|
|[[:human genes:u:utp23|UTP23]]|0.415|
|[[:human genes:p:pggt1b|PGGT1B]]|0.414|
|[[:human genes:t:trmt5|TRMT5]]|0.413|
|[[:human genes:l:lsm10|LSM10]]|0.412|
|[[:human genes:t:tmed10|TMED10]]|0.412|
|[[:human genes:t:tomm40|TOMM40]]|0.411|
|[[:human genes:d:dolk|DOLK]]|0.411|
|[[:human genes:s:slc25a19|SLC25A19]]|0.41|
|[[:human genes:a:asxl2|ASXL2]]|0.409|
|[[:human genes:w:wdr82|WDR82]]|0.408|
|[[:human genes:p:ppp4c|PPP4C]]|0.407|
|[[:human genes:t:trip12|TRIP12]]|0.407|
|[[:human genes:p:pdxk|PDXK]]|0.406|
|[[:human genes:m:mef2c|MEF2C]]|0.406|
|[[:human genes:a:adsl|ADSL]]|0.406|
|[[:human genes:d:ddx20|DDX20]]|0.406|
|[[:human genes:e:elac2|ELAC2]]|0.405|
|[[:human genes:a:atp5i|ATP5I]]|0.404|
|[[:human genes:p:pdpk1|PDPK1]]|0.404|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.403|
|[[:human genes:u:ube2j1|UBE2J1]]|0.403|
|[[:human genes:a:atp5h|ATP5H]]|0.402|
|[[:human genes:s:sec61g|SEC61G]]|0.401|
|[[:human genes:c:cmtr1|CMTR1]]|0.401|
|[[:human genes:f:fbxo11|FBXO11]]|0.4|
|[[:human genes:m:mrps33|MRPS33]]|0.4|
|[[:human genes:f:faf2|FAF2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 39/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|12/28|
|bone|0/26|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|3/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1465
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CBFB Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>