======= CBLN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CBLN1
  * **<color #00a2e8>Official Name</color>**: cerebellin 1 precursor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=869|869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23435|P23435]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CBLN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CBLN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600432|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511). {ECO:0000250|UniProtKB:Q9R171, ECO:0000269|PubMed:27418511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1q|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of long-term synaptic depression|
|cerebellar granular layer formation|
|cerebellar granule cell differentiation|
|cerebellar granular layer morphogenesis|
|negative regulation of excitatory postsynaptic potential|
|regulation of postsynaptic density assembly|
|regulation of postsynapse assembly|
|regulation of postsynaptic specialization assembly|
|cerebellar granular layer development|
|regulation of long-term synaptic depression|
|synaptic cleft|
|regulation of excitatory synapse assembly|
|regulation of postsynaptic density organization|
|parallel fiber to Purkinje cell synapse|
|cell differentiation in hindbrain|
|cerebellar cortex formation|
|negative regulation of nervous system process|
|regulation of presynapse assembly|
|cerebellar cortex morphogenesis|
|regulation of presynapse organization|
|cerebellum morphogenesis|
|modulation of excitatory postsynaptic potential|
|hindbrain morphogenesis|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|cerebellar cortex development|
|negative regulation of synaptic transmission|
|positive regulation of synapse assembly|
|regulation of postsynapse organization|
|cerebellum development|
|regulation of synapse assembly|
|metencephalon development|
|regulation of nervous system process|
|hindbrain development|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|central nervous system neuron differentiation|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|glutamatergic synapse|
|collagen-containing extracellular matrix|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|cell-cell adhesion|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|cell junction|
|regulation of system process|
|brain development|
|head development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|central nervous system development|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cell-cell signaling|
|secretion|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|establishment of protein localization|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8139
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CBLN1 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>