======= CCDC101 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGF29
  * **<color #00a2e8>Official Name</color>**: SAGA complex associated factor 29
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112869|112869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96ES7|Q96ES7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC101&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC101|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613374|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (PubMed:19103755, PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (PubMed:20850016, PubMed:26421618, PubMed:21685874, PubMed:26578293). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (PubMed:20850016). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (PubMed:23894581). {ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:21685874, ECO:0000269|PubMed:23894581, ECO:0000269|PubMed:26421618, ECO:0000269|PubMed:26578293}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1325|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II transcription regulator recruiting activity|
|SAGA-type complex|
|establishment of protein localization to chromatin|
|RNA polymerase II preinitiation complex assembly|
|establishment of protein localization to chromosome|
|Ada2/Gcn5/Ada3 transcription activator complex|
|SAGA complex|
|protein localization to chromatin|
|transcription preinitiation complex assembly|
|histone H3 acetylation|
|methylated histone binding|
|protein localization to chromosome|
|protein N-terminus binding|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|transcription initiation from RNA polymerase II promoter|
|protein acylation|
|protein-DNA complex assembly|
|DNA-templated transcription, initiation|
|protein-DNA complex subunit organization|
|peptidyl-lysine modification|
|enzyme binding|
|histone modification|
|covalent chromatin modification|
|establishment of protein localization to organelle|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|protein localization to organelle|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-3.18|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.64|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-2.34|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.25|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.25|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.21|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-2.19|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.16|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.07|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.07|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2.05|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.97|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.94|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.91|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.89|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.88|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.88|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.85|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.81|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.81|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.79|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.77|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.74|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.73|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.73|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.81|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.83|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.84|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.96|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.01|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.13|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.15|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.25|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.37|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.49|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.5|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.54|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.64|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.83|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.99|
|[[:results:exp539|42°C R08 exp539]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.664|
|[[:human genes:m:med16|MED16]]|0.655|
|[[:human genes:m:mllt1|MLLT1]]|0.652|
|[[:human genes:t:tle4|TLE4]]|0.623|
|[[:human genes:m:med23|MED23]]|0.622|
|[[:human genes:g:gnb1l|GNB1L]]|0.622|
|[[:human genes:t:taf5l|TAF5L]]|0.622|
|[[:human genes:a:aars|AARS]]|0.62|
|[[:human genes:d:dpagt1|DPAGT1]]|0.613|
|[[:human genes:t:tada1|TADA1]]|0.61|
|[[:human genes:g:gmppb|GMPPB]]|0.608|
|[[:human genes:t:taf6l|TAF6L]]|0.604|
|[[:human genes:i:id3|ID3]]|0.601|
|[[:human genes:r:rnmt|RNMT]]|0.597|
|[[:human genes:m:mtor|MTOR]]|0.594|
|[[:human genes:t:tti2|TTI2]]|0.593|
|[[:human genes:r:rtcb|RTCB]]|0.589|
|[[:human genes:w:wdr24|WDR24]]|0.577|
|[[:human genes:d:dohh|DOHH]]|0.572|
|[[:human genes:p:pelo|PELO]]|0.569|
|[[:human genes:p:pmm2|PMM2]]|0.568|
|[[:human genes:g:gfpt1|GFPT1]]|0.563|
|[[:human genes:m:mapk14|MAPK14]]|0.562|
|[[:human genes:t:tti1|TTI1]]|0.56|
|[[:human genes:s:supt7l|SUPT7L]]|0.558|
|[[:human genes:e:eif4e|EIF4E]]|0.55|
|[[:human genes:c:csnk2b|CSNK2B]]|0.546|
|[[:human genes:t:thoc6|THOC6]]|0.545|
|[[:human genes:o:otud5|OTUD5]]|0.542|
|[[:human genes:t:thg1l|THG1L]]|0.538|
|[[:human genes:f:fli1|FLI1]]|0.536|
|[[:human genes:u:ube2l3|UBE2L3]]|0.534|
|[[:human genes:a:alg2|ALG2]]|0.532|
|[[:human genes:t:tada3|TADA3]]|0.532|
|[[:human genes:c:cbfb|CBFB]]|0.527|
|[[:human genes:a:alg1|ALG1]]|0.526|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.526|
|[[:human genes:m:med25|MED25]]|0.517|
|[[:human genes:b:bap1|BAP1]]|0.516|
|[[:human genes:a:alg5|ALG5]]|0.515|
|[[:human genes:h:hspd1|HSPD1]]|0.513|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.508|
|[[:human genes:u:uhrf1|UHRF1]]|0.505|
|[[:human genes:u:usp22|USP22]]|0.505|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.505|
|[[:human genes:m:meaf6|MEAF6]]|0.502|
|[[:human genes:t:trim28|TRIM28]]|0.502|
|[[:human genes:m:maml1|MAML1]]|0.501|
|[[:human genes:v:vmp1|VMP1]]|0.499|
|[[:human genes:v:vhl|VHL]]|0.498|
|[[:human genes:w:wdr59|WDR59]]|0.498|
|[[:human genes:t:telo2|TELO2]]|0.497|
|[[:human genes:t:tada2b|TADA2B]]|0.496|
|[[:human genes:d:derl2|DERL2]]|0.496|
|[[:human genes:u:uap1|UAP1]]|0.495|
|[[:human genes:b:brpf1|BRPF1]]|0.495|
|[[:human genes:t:tmem41b|TMEM41B]]|0.493|
|[[:human genes:l:lmo2|LMO2]]|0.492|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.492|
|[[:human genes:n:nsd1|NSD1]]|0.49|
|[[:human genes:p:polr3h|POLR3H]]|0.489|
|[[:human genes:u:ube2g2|UBE2G2]]|0.488|
|[[:human genes:s:spcs3|SPCS3]]|0.486|
|[[:human genes:e:exoc4|EXOC4]]|0.485|
|[[:human genes:t:tmed10|TMED10]]|0.485|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.484|
|[[:human genes:m:med4|MED4]]|0.483|
|[[:human genes:z:znf592|ZNF592]]|0.483|
|[[:human genes:m:max|MAX]]|0.481|
|[[:human genes:r:rpp21|RPP21]]|0.48|
|[[:human genes:c:cbx3|CBX3]]|0.477|
|[[:human genes:e:eprs|EPRS]]|0.477|
|[[:human genes:n:nars|NARS]]|0.476|
|[[:human genes:d:dnajc3|DNAJC3]]|0.475|
|[[:human genes:d:dhx29|DHX29]]|0.474|
|[[:human genes:p:pam16|PAM16]]|0.474|
|[[:human genes:s:supt20h|SUPT20H]]|0.473|
|[[:human genes:p:pax5|PAX5]]|0.473|
|[[:human genes:e:eny2|ENY2]]|0.473|
|[[:human genes:h:hars|HARS]]|0.471|
|[[:human genes:a:alg14|ALG14]]|0.47|
|[[:human genes:y:yars|YARS]]|0.47|
|[[:human genes:n:nae1|NAE1]]|0.468|
|[[:human genes:a:atf7ip|ATF7IP]]|0.468|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.467|
|[[:human genes:t:triap1|TRIAP1]]|0.466|
|[[:human genes:a:atp5j|ATP5J]]|0.465|
|[[:human genes:b:brd9|BRD9]]|0.463|
|[[:human genes:a:adsl|ADSL]]|0.46|
|[[:human genes:t:tsen54|TSEN54]]|0.46|
|[[:human genes:u:ube3a|UBE3A]]|0.457|
|[[:human genes:m:med13|MED13]]|0.457|
|[[:human genes:a:alg13|ALG13]]|0.457|
|[[:human genes:c:cct7|CCT7]]|0.456|
|[[:human genes:t:trmt5|TRMT5]]|0.456|
|[[:human genes:s:ssbp2|SSBP2]]|0.455|
|[[:human genes:s:slc35b1|SLC35B1]]|0.454|
|[[:human genes:d:ddost|DDOST]]|0.454|
|[[:human genes:o:osgep|OSGEP]]|0.45|
|[[:human genes:t:tsen34|TSEN34]]|0.45|
|[[:human genes:s:smarcd1|SMARCD1]]|0.45|
|[[:human genes:d:dpf2|DPF2]]|0.447|
|[[:human genes:x:xpo6|XPO6]]|0.447|
|[[:human genes:s:srp68|SRP68]]|0.446|
|[[:human genes:s:spcs2|SPCS2]]|0.445|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.445|
|[[:human genes:d:dhdds|DHDDS]]|0.445|
|[[:human genes:a:arih1|ARIH1]]|0.445|
|[[:human genes:s:sox7|SOX7]]|0.444|
|[[:human genes:g:gpn2|GPN2]]|0.443|
|[[:human genes:z:znf259|ZNF259]]|0.442|
|[[:human genes:n:nxt1|NXT1]]|0.442|
|[[:human genes:z:zfx|ZFX]]|0.441|
|[[:human genes:a:asxl2|ASXL2]]|0.441|
|[[:human genes:h:hhex|HHEX]]|0.44|
|[[:human genes:p:polr3b|POLR3B]]|0.44|
|[[:human genes:c:crcp|CRCP]]|0.44|
|[[:human genes:z:znf608|ZNF608]]|0.439|
|[[:human genes:r:rpn1|RPN1]]|0.439|
|[[:human genes:s:seh1l|SEH1L]]|0.439|
|[[:human genes:d:dhps|DHPS]]|0.439|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.438|
|[[:human genes:l:lsmd1|LSMD1]]|0.438|
|[[:human genes:l:ldb1|LDB1]]|0.438|
|[[:human genes:u:uxt|UXT]]|0.438|
|[[:human genes:s:srp72|SRP72]]|0.437|
|[[:human genes:b:btaf1|BTAF1]]|0.436|
|[[:human genes:v:vrk1|VRK1]]|0.436|
|[[:human genes:f:fbxo11|FBXO11]]|0.435|
|[[:human genes:s:scaf8|SCAF8]]|0.434|
|[[:human genes:o:oraov1|ORAOV1]]|0.434|
|[[:human genes:z:zbtb11|ZBTB11]]|0.434|
|[[:human genes:a:atxn10|ATXN10]]|0.433|
|[[:human genes:u:ubr5|UBR5]]|0.433|
|[[:human genes:z:zbtb44|ZBTB44]]|0.431|
|[[:human genes:a:asb7|ASB7]]|0.431|
|[[:human genes:d:dad1|DAD1]]|0.43|
|[[:human genes:m:med18|MED18]]|0.43|
|[[:human genes:s:srp14|SRP14]]|0.43|
|[[:human genes:d:dcaf5|DCAF5]]|0.429|
|[[:human genes:v:vcpip1|VCPIP1]]|0.426|
|[[:human genes:h:hspa9|HSPA9]]|0.426|
|[[:human genes:z:znf410|ZNF410]]|0.425|
|[[:human genes:u:utp23|UTP23]]|0.425|
|[[:human genes:u:ube2j1|UBE2J1]]|0.423|
|[[:human genes:t:trim33|TRIM33]]|0.423|
|[[:human genes:t:trnt1|TRNT1]]|0.422|
|[[:human genes:t:tceb3|TCEB3]]|0.42|
|[[:human genes:t:trmt10a|TRMT10A]]|0.416|
|[[:human genes:l:lsm11|LSM11]]|0.416|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.415|
|[[:human genes:c:cars|CARS]]|0.415|
|[[:human genes:e:erg|ERG]]|0.415|
|[[:human genes:w:wars|WARS]]|0.414|
|[[:human genes:r:runx1|RUNX1]]|0.414|
|[[:human genes:t:tbcb|TBCB]]|0.414|
|[[:human genes:e:ercc2|ERCC2]]|0.413|
|[[:human genes:m:med13l|MED13L]]|0.411|
|[[:human genes:e:eef1e1|EEF1E1]]|0.409|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.409|
|[[:human genes:s:setdb1|SETDB1]]|0.408|
|[[:human genes:t:txnrd1|TXNRD1]]|0.407|
|[[:human genes:c:c21orf59|C21orf59]]|0.404|
|[[:human genes:p:pggt1b|PGGT1B]]|0.403|
|[[:human genes:a:ago2|AGO2]]|0.403|
|[[:human genes:a:alg11|ALG11]]|0.403|
|[[:human genes:t:tbca|TBCA]]|0.402|
|[[:human genes:a:atp5o|ATP5O]]|0.401|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.401|
|[[:human genes:t:trip12|TRIP12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 173/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|10/28|
|bone|6/25|
|breast|13/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/15|
|kidney|2/21|
|liver|4/20|
|lung|19/75|
|lymphocyte|4/14|
|ovary|5/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1129
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC101 Expression in NALM6 Cells: 3.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>