======= CCDC103 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC103
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 103
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=388389|388389]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IW40|Q8IW40]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC103&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC103|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains a coiled-coil domain. [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Dynein-attachment factor required for cilia motility. {ECO:0000269|PubMed:22581229}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|determination of digestive tract left/right asymmetry|
|outer dynein arm|
|epithelial cilium movement involved in determination of left/right asymmetry|
|inner dynein arm assembly|
|outer dynein arm assembly|
|epithelial cilium movement involved in extracellular fluid movement|
|extracellular transport|
|axonemal dynein complex assembly|
|cilium movement|
|heart looping|
|axoneme assembly|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube development|
|microtubule bundle formation|
|motile cilium|
|axoneme|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|digestive tract development|
|digestive system development|
|microtubule-based transport|
|heart morphogenesis|
|microtubule-based movement|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|cilium assembly|
|cilium organization|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|tube morphogenesis|
|microtubule-based process|
|organelle assembly|
|cellular protein-containing complex assembly|
|tube development|
|circulatory system development|
|protein homodimerization activity|
|animal organ morphogenesis|
|embryo development|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|tissue development|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.78|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3372
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC103 Expression in NALM6 Cells: -1.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>