======= CCDC116 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC116
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 116
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=164592|164592]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYX3|Q8IYX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC116&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC116|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centrosome|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.37|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.05|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.01|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.8|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.78|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.98|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.517|
|[[:human genes:t:tceb3c|TCEB3C]]|0.5|
|[[:human genes:p:pola1|POLA1]]|0.499|
|[[:human genes:e:exosc9|EXOSC9]]|0.499|
|[[:human genes:p:psmb4|PSMB4]]|0.492|
|[[:human genes:c:chd4|CHD4]]|0.485|
|[[:human genes:p:psma7|PSMA7]]|0.485|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.48|
|[[:human genes:r:rpl35|RPL35]]|0.479|
|[[:human genes:p:psma6|PSMA6]]|0.478|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.474|
|[[:human genes:m:mt1e|MT1E]]|0.473|
|[[:human genes:u:upf1|UPF1]]|0.47|
|[[:human genes:c:cdc45|CDC45]]|0.469|
|[[:human genes:g:golga8o|GOLGA8O]]|0.469|
|[[:human genes:c:cbwd5|CBWD5]]|0.467|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.466|
|[[:human genes:c:cbwd3|CBWD3]]|0.466|
|[[:human genes:c:col2a1|COL2A1]]|0.465|
|[[:human genes:p:polr2j3|POLR2J3]]|0.464|
|[[:human genes:r:rps12|RPS12]]|0.461|
|[[:human genes:p:psmc5|PSMC5]]|0.461|
|[[:human genes:n:nupl1|NUPL1]]|0.458|
|[[:human genes:k:krt78|KRT78]]|0.454|
|[[:human genes:d:ddx56|DDX56]]|0.454|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.453|
|[[:human genes:r:rilpl2|RILPL2]]|0.452|
|[[:human genes:s:slc6a17|SLC6A17]]|0.448|
|[[:human genes:p:pola2|POLA2]]|0.446|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.446|
|[[:human genes:c:ccna2|CCNA2]]|0.444|
|[[:human genes:g:gid4|GID4]]|0.444|
|[[:human genes:l:loc643669|LOC643669]]|0.444|
|[[:human genes:r:rpl6|RPL6]]|0.443|
|[[:human genes:p:ppm1d|PPM1D]]|0.442|
|[[:human genes:h:hivep3|HIVEP3]]|0.441|
|[[:human genes:c:cactin|CACTIN]]|0.44|
|[[:human genes:p:paf1|PAF1]]|0.439|
|[[:human genes:c:c14orf93|C14orf93]]|0.439|
|[[:human genes:x:xylt2|XYLT2]]|0.439|
|[[:human genes:c:cbwd6|CBWD6]]|0.437|
|[[:human genes:d:ddtl|DDTL]]|0.436|
|[[:human genes:e:exosc6|EXOSC6]]|0.435|
|[[:human genes:r:rps5|RPS5]]|0.435|
|[[:human genes:z:znf574|ZNF574]]|0.434|
|[[:human genes:t:ticrr|TICRR]]|0.434|
|[[:human genes:r:rps7|RPS7]]|0.433|
|[[:human genes:w:wdr75|WDR75]]|0.432|
|[[:human genes:a:art5|ART5]]|0.43|
|[[:human genes:b:bysl|BYSL]]|0.43|
|[[:human genes:n:narfl|NARFL]]|0.429|
|[[:human genes:r:rps2|RPS2]]|0.429|
|[[:human genes:t:twistnb|TWISTNB]]|0.429|
|[[:human genes:s:slc4a1|SLC4A1]]|0.429|
|[[:human genes:c:chaf1a|CHAF1A]]|0.428|
|[[:human genes:u:utp3|UTP3]]|0.428|
|[[:human genes:p:psmb1|PSMB1]]|0.428|
|[[:human genes:s:ssh2|SSH2]]|0.426|
|[[:human genes:c:cln6|CLN6]]|0.424|
|[[:human genes:z:znf541|ZNF541]]|0.423|
|[[:human genes:n:nelfcd|NELFCD]]|0.423|
|[[:human genes:v:vasn|VASN]]|0.422|
|[[:human genes:n:npipb5|NPIPB5]]|0.421|
|[[:human genes:m:mcoln1|MCOLN1]]|0.421|
|[[:human genes:p:psmb2|PSMB2]]|0.42|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.42|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.42|
|[[:human genes:p:pwp2|PWP2]]|0.42|
|[[:human genes:m:myo1h|MYO1H]]|0.418|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.418|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.418|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.417|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.417|
|[[:human genes:p:psmd1|PSMD1]]|0.417|
|[[:human genes:l:lrr1|LRR1]]|0.417|
|[[:human genes:a:atp13a1|ATP13A1]]|0.416|
|[[:human genes:n:nol10|NOL10]]|0.414|
|[[:human genes:s:smg7|SMG7]]|0.413|
|[[:human genes:r:rad51|RAD51]]|0.413|
|[[:human genes:a:acsf2|ACSF2]]|0.412|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.412|
|[[:human genes:z:zfand5|ZFAND5]]|0.412|
|[[:human genes:c:cebpz|CEBPZ]]|0.412|
|[[:human genes:e:exosc5|EXOSC5]]|0.411|
|[[:human genes:x:xab2|XAB2]]|0.41|
|[[:human genes:n:nbpf10|NBPF10]]|0.41|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.41|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.409|
|[[:human genes:a:ankle1|ANKLE1]]|0.409|
|[[:human genes:d:disp2|DISP2]]|0.409|
|[[:human genes:i:ik|IK]]|0.408|
|[[:human genes:m:madcam1|MADCAM1]]|0.408|
|[[:human genes:c:cdt1|CDT1]]|0.407|
|[[:human genes:c:cep192|CEP192]]|0.406|
|[[:human genes:r:rrp7a|RRP7A]]|0.406|
|[[:human genes:p:psmc2|PSMC2]]|0.406|
|[[:human genes:t:tpx2|TPX2]]|0.406|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.406|
|[[:human genes:s:s1pr4|S1PR4]]|0.405|
|[[:human genes:p:psmd14|PSMD14]]|0.405|
|[[:human genes:k:kctd17|KCTD17]]|0.403|
|[[:human genes:t:timeless|TIMELESS]]|0.403|
|[[:human genes:d:dtl|DTL]]|0.403|
|[[:human genes:d:ddx47|DDX47]]|0.403|
|[[:human genes:d:dock6|DOCK6]]|0.403|
|[[:human genes:a:acbd4|ACBD4]]|0.403|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.402|
|[[:human genes:p:psmd2|PSMD2]]|0.402|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.402|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.402|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.401|
|[[:human genes:z:znf830|ZNF830]]|0.401|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.401|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.401|
|[[:human genes:t:tfip11|TFIP11]]|0.4|
|[[:human genes:g:golga8r|GOLGA8R]]|0.4|
|[[:human genes:c:ctr9|CTR9]]|0.4|
|[[:human genes:p:pan3|PAN3]]|0.4|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2021
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC116 Expression in NALM6 Cells: -0.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>