======= CCDC79 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TERB1
  * **<color #00a2e8>Official Name</color>**: telomere repeat binding bouquet formation protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=283847|283847]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NA31|Q8NA31]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC79&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC79|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617332|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1- TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity. {ECO:0000250|UniProtKB:Q8C0V1}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic telomere tethering at nuclear periphery|
|chromosome attachment to the nuclear envelope|
|meiotic attachment of telomere to nuclear envelope|
|telomere tethering at nuclear periphery|
|shelterin complex|
|meiotic telomere clustering|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|telomere localization|
|nuclear inner membrane|
|synapsis|
|chromosome, telomeric region|
|homologous chromosome segregation|
|chromosome organization involved in meiotic cell cycle|
|establishment of chromosome localization|
|chromosome localization|
|meiotic chromosome segregation|
|meiosis I|
|nuclear chromosome, telomeric region|
|meiosis I cell cycle process|
|meiotic nuclear division|
|meiotic cell cycle process|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|organelle localization|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|DNA binding|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.86|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.79|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.73|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14309
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.22 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC79 Expression in NALM6 Cells: 2.22'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>