======= CCDC94 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YJU2
  * **<color #00a2e8>Official Name</color>**: YJU2 splicing factor homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55702|55702]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BW85|Q9BW85]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC94&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC94|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF572|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type catalytic step 1 spliceosome|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of signal transduction by p53 class mediator|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|negative regulation of response to DNA damage stimulus|
|regulation of signal transduction by p53 class mediator|
|regulation of response to DNA damage stimulus|
|RNA splicing|
|mRNA processing|
|negative regulation of intracellular signal transduction|
|mRNA metabolic process|
|regulation of cellular response to stress|
|RNA processing|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|negative regulation of response to stimulus|
|RNA metabolic process|
|regulation of intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.03|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.73|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.73|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.75|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.85|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.86|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.88|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.91|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.99|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.99|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.12|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.14|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.557|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.531|
|[[:human genes:p:polr2j3|POLR2J3]]|0.527|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.519|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.517|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.505|
|[[:human genes:h:hap1|HAP1]]|0.504|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.502|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.502|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.501|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.501|
|[[:human genes:t:tceb3c|TCEB3C]]|0.498|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.497|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.49|
|[[:human genes:p:psmd1|PSMD1]]|0.49|
|[[:human genes:t:ticrr|TICRR]]|0.488|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.487|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.482|
|[[:human genes:a:akirin2|AKIRIN2]]|0.471|
|[[:human genes:p:plk4|PLK4]]|0.471|
|[[:human genes:c:cwc22|CWC22]]|0.47|
|[[:human genes:c:c14orf93|C14orf93]]|0.468|
|[[:human genes:p:psmb4|PSMB4]]|0.466|
|[[:human genes:p:psmd3|PSMD3]]|0.465|
|[[:human genes:s:stil|STIL]]|0.465|
|[[:human genes:r:rpl34|RPL34]]|0.459|
|[[:human genes:r:rrp15|RRP15]]|0.458|
|[[:human genes:c:chd4|CHD4]]|0.456|
|[[:human genes:o:orc1|ORC1]]|0.455|
|[[:human genes:p:psmc6|PSMC6]]|0.453|
|[[:human genes:r:rad51|RAD51]]|0.453|
|[[:human genes:p:psmd11|PSMD11]]|0.452|
|[[:human genes:c:cope|COPE]]|0.451|
|[[:human genes:v:vasn|VASN]]|0.451|
|[[:human genes:l:lrr1|LRR1]]|0.448|
|[[:human genes:t:tfip11|TFIP11]]|0.448|
|[[:human genes:z:znf830|ZNF830]]|0.448|
|[[:human genes:p:pcf11|PCF11]]|0.447|
|[[:human genes:m:myo18a|MYO18A]]|0.447|
|[[:human genes:c:copa|COPA]]|0.446|
|[[:human genes:m:mt1e|MT1E]]|0.444|
|[[:human genes:c:ccna2|CCNA2]]|0.44|
|[[:human genes:s:sf3a1|SF3A1]]|0.439|
|[[:human genes:s:syt9|SYT9]]|0.439|
|[[:human genes:c:cwc15|CWC15]]|0.436|
|[[:human genes:s:supt6h|SUPT6H]]|0.434|
|[[:human genes:w:wdr87|WDR87]]|0.434|
|[[:human genes:n:ndc1|NDC1]]|0.433|
|[[:human genes:s:snrpa1|SNRPA1]]|0.433|
|[[:human genes:c:cdc45|CDC45]]|0.432|
|[[:human genes:r:rrn3|RRN3]]|0.431|
|[[:human genes:n:nup43|NUP43]]|0.43|
|[[:human genes:f:fam25b|FAM25B]]|0.429|
|[[:human genes:c:copz1|COPZ1]]|0.429|
|[[:human genes:m:myo1h|MYO1H]]|0.426|
|[[:human genes:p:psma6|PSMA6]]|0.426|
|[[:human genes:n:nupl1|NUPL1]]|0.426|
|[[:human genes:l:lad1|LAD1]]|0.426|
|[[:human genes:w:wdr43|WDR43]]|0.424|
|[[:human genes:p:psmc5|PSMC5]]|0.424|
|[[:human genes:z:znf106|ZNF106]]|0.424|
|[[:human genes:f:fam231a|FAM231A]]|0.423|
|[[:human genes:a:aqr|AQR]]|0.423|
|[[:human genes:g:gnb3|GNB3]]|0.423|
|[[:human genes:f:fam231c|FAM231C]]|0.422|
|[[:human genes:c:cmya5|CMYA5]]|0.421|
|[[:human genes:a:arcn1|ARCN1]]|0.421|
|[[:human genes:r:rps14|RPS14]]|0.421|
|[[:human genes:s:sel1l|SEL1L]]|0.42|
|[[:human genes:c:cgb2|CGB2]]|0.418|
|[[:human genes:r:rnf113a|RNF113A]]|0.417|
|[[:human genes:t:terf2|TERF2]]|0.417|
|[[:human genes:t:top1mt|TOP1MT]]|0.417|
|[[:human genes:t:twistnb|TWISTNB]]|0.416|
|[[:human genes:e:exosc3|EXOSC3]]|0.415|
|[[:human genes:z:zfand5|ZFAND5]]|0.415|
|[[:human genes:n:npipb5|NPIPB5]]|0.415|
|[[:human genes:d:ddtl|DDTL]]|0.414|
|[[:human genes:m:med29|MED29]]|0.413|
|[[:human genes:s:sart1|SART1]]|0.41|
|[[:human genes:i:ik|IK]]|0.409|
|[[:human genes:h:hivep3|HIVEP3]]|0.409|
|[[:human genes:z:znf655|ZNF655]]|0.409|
|[[:human genes:p:psmc2|PSMC2]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.407|
|[[:human genes:c:cbwd3|CBWD3]]|0.407|
|[[:human genes:c:ckap5|CKAP5]]|0.407|
|[[:human genes:r:rps9|RPS9]]|0.407|
|[[:human genes:i:ints6|INTS6]]|0.406|
|[[:human genes:r:ranbp2|RANBP2]]|0.406|
|[[:human genes:n:nsf|NSF]]|0.405|
|[[:human genes:p:psmb1|PSMB1]]|0.405|
|[[:human genes:f:fcn2|FCN2]]|0.405|
|[[:human genes:r:rpl35|RPL35]]|0.405|
|[[:human genes:r:rnf4|RNF4]]|0.404|
|[[:human genes:c:cdc73|CDC73]]|0.404|
|[[:human genes:r:rps2|RPS2]]|0.404|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.404|
|[[:human genes:p:pan2|PAN2]]|0.403|
|[[:human genes:r:rad21|RAD21]]|0.402|
|[[:human genes:t:tspy8|TSPY8]]|0.402|
|[[:human genes:m:myb|MYB]]|0.402|
|[[:human genes:c:cep192|CEP192]]|0.401|
|[[:human genes:m:mat2a|MAT2A]]|0.401|
|[[:human genes:a:ankle2|ANKLE2]]|0.401|
|[[:human genes:c:cox8a|COX8A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 729/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 60
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC94 Expression in NALM6 Cells: 3.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>