======= CCL19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL19
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6363|6363]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99731|Q99731]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602227|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of dendritic cell dendrite assembly|
|interleukin-12 secretion|
|CCR7 chemokine receptor binding|
|myeloid dendritic cell chemotaxis|
|regulation of dendritic cell dendrite assembly|
|CCR10 chemokine receptor binding|
|interleukin-12 production|
|mature conventional dendritic cell differentiation|
|positive regulation of T-helper 1 cell differentiation|
|establishment of T cell polarity|
|negative regulation of dendritic cell apoptotic process|
|establishment of lymphocyte polarity|
|positive regulation of dendritic cell antigen processing and presentation|
|chemokine receptor binding|
|positive regulation of antigen processing and presentation|
|regulation of dendritic cell apoptotic process|
|regulation of T-helper 1 cell differentiation|
|regulation of dendritic cell antigen processing and presentation|
|immunological synapse formation|
|dendritic cell chemotaxis|
|response to nitric oxide|
|regulation of antigen processing and presentation|
|positive regulation of glycoprotein biosynthetic process|
|positive regulation of T-helper 1 type immune response|
|positive regulation of T-helper cell differentiation|
|dendritic cell migration|
|positive regulation of glycoprotein metabolic process|
|response to prostaglandin E|
|positive regulation of neutrophil chemotaxis|
|positive regulation of granulocyte chemotaxis|
|regulation of T-helper 1 type immune response|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|CCR chemokine receptor binding|
|response to prostaglandin|
|dendritic cell differentiation|
|positive regulation of phosphatidylinositol 3-kinase activity|
|cellular response to virus|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|positive regulation of interleukin-12 production|
|regulation of neutrophil migration|
|positive regulation of lipid kinase activity|
|positive regulation of interleukin-1 secretion|
|activation of JUN kinase activity|
|regulation of glycoprotein biosynthetic process|
|regulation of granulocyte chemotaxis|
|monocyte chemotaxis|
|regulation of glycoprotein metabolic process|
|positive regulation of alpha-beta T cell differentiation|
|negative regulation of leukocyte apoptotic process|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|lymphocyte chemotaxis|
|regulation of interleukin-1 beta secretion|
|mononuclear cell migration|
|cytokine secretion|
|positive regulation of phospholipid metabolic process|
|chemokine activity|
|response to bronchodilator|
|positive regulation of interleukin-1 beta production|
|positive regulation of receptor-mediated endocytosis|
|regulation of phosphatidylinositol 3-kinase activity|
|T cell costimulation|
|regulation of interleukin-1 secretion|
|regulation of interleukin-12 production|
|release of sequestered calcium ion into cytosol|
|lymphocyte costimulation|
|negative regulation of sequestering of calcium ion|
|positive regulation of interleukin-1 production|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of lipid kinase activity|
|regulation of alpha-beta T cell differentiation|
|lymphocyte migration|
|calcium ion transmembrane import into cytosol|
|cell-cell recognition|
|positive regulation of JUN kinase activity|
|calcium ion transport into cytosol|
|positive regulation of NIK/NF-kappaB signaling|
|chemokine-mediated signaling pathway|
|cell|
|regulation of interleukin-1 beta production|
|JNK cascade|
|regulation of leukocyte apoptotic process|
|neutrophil chemotaxis|
|positive regulation of T cell differentiation|
|response to fatty acid|
|regulation of phospholipid metabolic process|
|positive regulation of tumor necrosis factor production|
|regulation of JUN kinase activity|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|cytosolic calcium ion transport|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|regulation of interleukin-1 production|
|positive regulation of endocytosis|
|granulocyte migration|
|regulation of receptor-mediated endocytosis|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of plasma membrane bounded cell projection assembly|
|stress-activated MAPK cascade|
|positive regulation of adaptive immune response|
|regulation of NIK/NF-kappaB signaling|
|myeloid leukocyte differentiation|
|regulation of leukocyte chemotaxis|
|establishment of cell polarity|
|regulation of sequestering of calcium ion|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of chemotaxis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|positive regulation of cytokine secretion|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|positive regulation of lipid metabolic process|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte chemotaxis|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of tumor necrosis factor superfamily cytokine production|
|activation of MAPK activity|
|regulation of T cell proliferation|
|cell maturation|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of adaptive immune response|
|cellular response to interferon-gamma|
|positive regulation of protein kinase B signaling|
|protein localization to extracellular region|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of lymphocyte differentiation|
|peptide secretion|
|cellular response to interleukin-1|
|response to interferon-gamma|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|positive regulation of hemopoiesis|
|response to ketone|
|response to reactive oxygen species|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|calcium ion transmembrane transport|
|response to interleukin-1|
|regulation of plasma membrane bounded cell projection assembly|
|positive regulation of T cell activation|
|regulation of cell projection assembly|
|regulation of cytokine secretion|
|regulation of endocytosis|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|myeloid cell differentiation|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|response to alcohol|
|regulation of stress-activated MAPK cascade|
|T cell activation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cell recognition|
|cellular response to tumor necrosis factor|
|developmental maturation|
|calcium ion transport|
|positive regulation of cell-cell adhesion|
|positive regulation of MAP kinase activity|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|response to virus|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|regulation of leukocyte cell-cell adhesion|
|divalent inorganic cation transport|
|regulation of T cell activation|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|leukocyte differentiation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|positive regulation of lymphocyte activation|
|MAPK cascade|
|leukocyte migration|
|positive regulation of cell projection organization|
|lymphocyte activation|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|chemotaxis|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|taxis|
|cellular metal ion homeostasis|
|hemopoiesis|
|inorganic cation transmembrane transport|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|innate immune response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|cation transport|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|ion transmembrane transport|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|transmembrane transport|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL19 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>